Results 11 to 20 of about 342,736 (199)

Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions

Scientific Reports, 2021
Pyruvate functions as a key molecule in energy production and as an antioxidant. The efficacy of pyruvate supplementation in diabetic retinopathy and nephropathy has been shown in animal models; however, its significance in the functional maintenance of ...
Hideji Yako, Naoko Niimi, Ayako Kato, Shizuka Takaku, Yasuaki Tatsumi, Yasumasa Nishito, Koichi Kato, Kazunori Sango   +7 more
doaj   +1 more source

Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1

Cells, 2023
Chikungunya virus is an arthropod-borne infectious agent that causes Chikungunya fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly the extremities but also the large joints such as the knees.
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri   +18 more
doaj   +1 more source

Ehrlich Tumor Induces TRPV1-Dependent Evoked and Non-Evoked Pain-like Behavior in Mice

Brain Sciences, 2022
We standardized a model by injecting Ehrlich tumor cells into the paw to evaluate cancer pain mechanisms and pharmacological treatments. Opioid treatment, but not cyclooxygenase inhibitor or tricyclic antidepressant treatments reduces Ehrlich tumor pain.
Mariana M. Bertozzi, Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro, Victor Fattori, Larissa Staurengo-Ferrari, Camila R. Ferraz, Talita P. Domiciano, Cassia Calixto-Campos, Sergio M. Borghi, Ana C. Zarpelon, Thiago M. Cunha, Rubia Casagrande, Waldiceu A. Verri   +13 more
doaj   +1 more source

Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms

Frontiers in Immunology, 2023
BackgroundLipoxin A4 (LXA4) has anti-inflammatory and pro-resolutive roles in inflammation. We evaluated the effects and mechanisms of action of LXA4 in titanium dioxide (TiO2) arthritis, a model of prosthesis-induced joint inflammation and pain ...
Telma Saraiva-Santos, Telma Saraiva-Santos, Tiago H. Zaninelli, Tiago H. Zaninelli, Tiago H. Zaninelli, Marília F. Manchope, Ketlem C. Andrade, Camila R. Ferraz, Mariana M. Bertozzi, Nayara A. Artero, Anelise Franciosi, Stephanie Badaro-Garcia, Larissa Staurengo-Ferrari, Sergio M. Borghi, Sergio M. Borghi, Graziela S. Ceravolo, Avacir Casanova Andrello, Janaína Menezes Zanoveli, Michael S. Rogers, Rubia Casagrande, Felipe A. Pinho-Ribeiro, Waldiceu A. Verri   +21 more
doaj   +1 more source

Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments

Frontiers in Neurology, 2017
BackgroundTrench foot, or non-freezing cold injury (NFCI), results from cold exposure of sufficient severity and duration above freezing point, with consequent sensory and vascular abnormalities which may persist for years.
Praveen Anand, Rosario Privitera, Yiangos Yiangou, Philippe Donatien, Rolfe Birch, Peter Misra   +5 more
doaj   +1 more source

Formulated Curcumin Prevents Paclitaxel-Induced Peripheral Neuropathy through Reduction in Neuroinflammation by Modulation of α7 Nicotinic Acetylcholine Receptors

Pharmaceutics, 2022
Paclitaxel is widely used in the treatment of various types of solid malignancies. Paclitaxel-induced peripheral neuropathy (PIPN) is often characterized by burning pain, cold, and mechanical allodynia in patients.
Martial Caillaud, Danielle Thompson, Wisam Toma, Alyssa White, Jared Mann, Jane L. Roberts, John W. Bigbee, David A. Gewirtz, M. Imad Damaj   +8 more
doaj   +1 more source

Diabetic neuropathies [PDF]

Diabetologia, 2000
Diabetic neuropathy is a common complication of diabetes that is often associated both with considerable morbidity and mortality. The epidemiology and natural course of diabetic neuropathy is clouded with uncertainty, largely due to confusion regarding the definition and measurement of this disorder.
A I, Vinik, T S, Park, K B, Stansberry, G L, Pittenger   +3 more
openaire   +2 more sources

Nutritional optic and peripheral neuropathy: a case report. [PDF]

, 2009
INTRODUCTION: The link between nutritional status and either optic or peripheral neuropathies is well established with tobacco, ethanol, deficiencies in thiamine, vitamin A, B12, B3 and B6 and protein-energy malnutrition all being causative.
Nightingale, LM, Laura M Nightingale, Paviour, DC, Dominic C Paviour   +3 more
core   +1 more source

Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells

Cancer Cell International, 2018
Background Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-
Eun Jung Sohn, Kyoung-mi Bak, Yun-kyeong Nam, Hwan Tae Park   +3 more
doaj   +1 more source

[Ru(bpy)2(NO)SO3](PF6), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice

Frontiers in Pharmacology, 2019
Monosodium urate crystals (MSU) deposition induces articular inflammation known as gout. This disease is characterized by intense articular inflammation and pain by mechanisms involving the activation of the transcription factor NFκB and inflammasome ...
Ana C. Rossaneis, Daniela T. Longhi-Balbinot, Mariana M. Bertozzi, Victor Fattori, Carina Z. Segato-Vendrameto, Stephanie Badaro-Garcia, Tiago H. Zaninelli, Larissa Staurengo-Ferrari, Sergio M. Borghi, Thacyana T. Carvalho, Allan J. C. Bussmann, Florêncio S. Gouveia, Luiz G. F. Lopes, Rubia Casagrande, Waldiceu A. Verri   +14 more
doaj   +1 more source