NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li +6 more
wiley +1 more source
Normalized EMG Amplitude During Repeated Sit-to-Stand Transfers in Patients with Diabetic Peripheral Neuropathy. [PDF]
Ullah S, Iqbal K, Rizwan M.
europepmc +1 more source
SGLT2i use and fracture risk compared with DPP4i in patients with T2DM
ABSTRACT Introduction The association between sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment‐naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy after prior dipeptidyl peptidase‐4 inhibitor (DPP4i) use.
Sung‐Yen Lin +5 more
wiley +1 more source
Nerve decompressive surgery of the lower limbs for diabetic peripheral neuropathy: a systematic review and meta-analysis. [PDF]
Zhao Y +8 more
europepmc +1 more source
Clinical Significance of Serum CCR2 and IDO1 in Diabetic Peripheral Neuropathy. [PDF]
Liu Y, Yang Q.
europepmc +1 more source
In this exploratory case–control study, plasma PLP (vitamin B6), homocysteine and ACTH concentrations did not differ between patients with burning mouth syndrome (BMS) and controls, and none discriminated patients individually. Within patients, however, psychological distress mapped onto a homocysteine–ACTH relationship from which PLP appeared ...
Ashley Lebel +3 more
wiley +1 more source
Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease. [PDF]
Wiggers A +9 more
europepmc +1 more source
Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw +4 more
wiley +1 more source
Clinical Diabetic Peripheral Neuropathy: Can It Be Reversed? Arguments for and Against From a NEUROdiab Debate. [PDF]
Sloan G +9 more
europepmc +1 more source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source

