Results 81 to 90 of about 1,023,691 (284)

Diabetic peripheral neuropathy among adult type 2 diabetes patients in Adama, Ethiopia: health facility-based study

Scientific Reports
Diabetic peripheral neuropathy is the most prominent microvascular complication of diabetes mellitus and the leading cause of ulceration, amputation, and extended hospitalization.
Yohannes Mekuria Negussie, Nardos Tilahun Bekele   +1 more
doaj   +1 more source

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy [PDF]

Clinical Therapeutics, 2018
Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution.
Iqbal, Zohaib, Azmi, Shazli, Yadav, Rahul, Ferdousi, Maryam; id_orcid 0000-0002-7989-8233, Kumar, Mohit, Cuthbertson, Daniel J., Lim, Jonathan, Malik, Rayaz A., Alam, Uazman   +8 more
openaire   +2 more sources

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Diagnosis and rational treatment of painful diabetic peripheral neuropathy: an interdisciplinary expert consensus

Сахарный диабет, 2019
Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus, significantly impairing well-being, quality of life and functioning of patients.
Gagik R. Galstyan, Elena G. Starostina, Nikolay N. Yakhno, Irina V. Gurieva, Maxim V. Churyukanov, Igor A. Strokov, Alla Y. Tokmakova, Mikhail L. Kukushkin, Anatoly I. Martynov, Marina V. Shestakova   +9 more
doaj   +1 more source

Exposure–Response Analysis of Enfortumab Vedotin Plus Pembrolizumab as First‐Line Therapy for Locally Advanced or Metastatic Urothelial Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Enfortumab vedotin is a nectin‐4‐directed antibody–drug conjugate currently approved in combination with pembrolizumab for the first‐line treatment of locally advanced or metastatic urothelial cancer. Here we describe the exposure–response relationship between enfortumab vedotin exposures and efficacy/safety endpoints in patients who received ≥1 dose ...
Vaishali L. Chudasama, Helen Kastrissios, Hossam Kadry, Daping Zhang, Salaheldin Hamed, Srinivasu Poondru, Souvik Bhattacharya, Russ Wada, Amit Garg, Yen Lin Chia   +9 more
wiley   +1 more source

Thymosin β4 promotes the recovery of peripheral neuropathy in type II diabetic mice

Neurobiology of Disease, 2012
Peripheral neuropathy is one of the most common complications of diabetes mellitus. Using a mouse model of diabetic peripheral neuropathy, we tested the hypothesis that thymosin β4 (Tβ4) ameliorates diabetes‐induced neurovascular dysfunction in the ...
Lei Wang, Michael Chopp, Alexandra Szalad, Zhongwu Liu, Mei Lu, Li Zhang, Jing Zhang, Rui Lan Zhang, Dan Morris, Zheng Gang Zhang   +9 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Diabetic microangiopathy in Type 1 (insulin-dependent) diabetic patients after successful pancreatic and kidney or solitary kidney transplantation [PDF]

, 1991
To evaluate the beneficial effect of pancreatic grafting on peripheral microcirculation and long-term clinical outcome, we compared data of 28 Type 1 (insulin-dependent) diabetic patients either given a pancreatic and kidney graft simultaneously or given
W. Land, Illner, Wolf-Dieter, R. Landgraf, D. Abendroth, Land, Walter, W. -D. Illner, Schmand, J., J. Schmand, Abendroth, D., Landgraf, R.   +9 more
core   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng   +21 more
core   +1 more source