Results 1 to 10 of about 697,402 (235)

Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes

Annals of Clinical and Translational Neurology, 2021
Objective The global rise in type 2 diabetes is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes complication and is associated with poor outcomes.
Amy E. Rumora, Kai Guo, Fadhl M. Alakwaa, Signe T. Andersen, Evan L. Reynolds, Marit E. Jørgensen, Daniel R. Witte, Hatice Tankisi, Morten Charles, Masha G. Savelieff, Brian C. Callaghan, Troels S. Jensen, Eva L. Feldman   +12 more
doaj   +2 more sources

RAGE activation in macrophages and development of experimental diabetic polyneuropathy. [PDF]

JCI Insight, 2022
It is suggested that activation of receptor for advanced glycation end products (RAGE) induces proinflammatory response in diabetic nerve tissues.
Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, Sasaki T, Kudoh K, Ito K, Sango K, Nagai R, Yamamoto Y, Daimon M, Yamamoto H, Yagihashi S.   +14 more
europepmc   +2 more sources

Lumos for the long trail: Strategies for clinical diagnosis and severity staging for diabetic polyneuropathy and future directions

Journal of Diabetes Investigation, 2020
Diabetic polyneuropathy, which is a chronic symmetrical length‐dependent sensorimotor polyneuropathy, is the most common form of diabetic neuropathy. Although diabetic polyneuropathy is the most important risk factor in cases of diabetic foot, given its ...
Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura   +2 more
doaj   +2 more sources

Clinical use of an analysis of oxidative stress and IL-6 as the promoters of diabetic polyneuropathy [PDF]

Medicinski Glasnik, 2021
Aim To investigate interleukin 6 (IL-6) values depending on duration of diabetes mellitus (DM) and evaluate possible correlation with diabetic polyneuropathy.
Emina Karahmet, Besim Prnjavorac, Tamer Bego, Adaleta Softić, Lejla Begić, Edin Begić, Esma Karahmet, Lejla Prnjavorac, Irfan Prnjavorac   +8 more
doaj   +2 more sources

Neurobiological Opportunities in Diabetic Polyneuropathy

Neurotherapeutics, 2021
This review highlights a selection of potential translational directions for the treatment of diabetic polyneuropathy (DPN) currently irreversible and without approved interventions beyond pain management. The list does not include all diabetic targets that have been generated over several decades of research but focuses on newer work.
Trevor M. Poitras, Easton Munchrath, Douglas W. Zochodne   +2 more
openaire   +3 more sources

Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice

Cells, 2021
Dental pulp stem cells (DPSCs) are suitable for use in regenerative medicine. Cryopreserved human DPSCs (hDPSCs) ameliorate diabetic polyneuropathy, and the effects of hDPSC transplantation are related to VEGF and NGF secretion.
Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Hitoshi Miyachi, Shogo Ozawa, Ken Miyazawa, Akio Mitani, Toru Nagao, Shigemi Goto, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse   +19 more
doaj   +2 more sources

Conditioned media from dental pulp stem cells improved diabetic polyneuropathy through anti‐inflammatory, neuroprotective and angiogenic actions: Cell‐free regenerative medicine for diabetic polyneuropathy

Journal of Diabetes Investigation, 2019
Aims/Introduction Dental pulp stem cells (DPSCs) can be easily obtained from teeth for general orthodontic reasons. We have previously reported the therapeutic effects of DPSC transplantation for diabetic polyneuropathy. As abundant secretomes from DPSCs
Eriko Makino, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Saki Kanada, Masaki Hata, Tomokazu Saiki, Kazunori Sango, Hideki Kamiya, Jiro Nakamura, Ken Miyazawa, Shigemi Goto, Tatsuaki Matsubara, Keiko Naruse   +13 more
doaj   +2 more sources

Relationship between the progression of diabetic polyneuropathy and impaired circadian blood pressure variability [PDF]

Journal of Diabetes Investigation
Aims/Introduction We evaluated the 24‐h ambulatory blood pressure monitoring data of patients to investigate the relationship between the progression of diabetic polyneuropathy and impaired circadian blood pressure variability. Materials and Methods This
Dai Yamagami, Takahisa Deguchi, Aiko Arimura, Yoshihiko Nishio   +3 more
doaj   +2 more sources

Molecular Underpinnings of Diabetic Polyneuropathy [PDF]

Journal of Applied Physiology, 2016
to the editor: Allen and colleagues ([2][1]) provided an in-depth review of the pathophysiology and functional outcomes of diabetic polyneuropathy (DPN) among patients with diabetes mellitus (DM).
Hunter, Sandra K., Senefeld, Jonathon
core   +5 more sources

Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy in streptozotocin-induced diabetic nude mice: the role of angiogenic and neurotrophic factors

Stem Cell Research & Therapy, 2020
Background Dental pulp stem cells (DPSCs) have high proliferation and multi-differentiation capabilities that maintain their functionality after cryopreservation.
Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tomokazu Saiki, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Shogo Ozawa, Ken Miyazawa, Kenichi Kurita, Shigemi Goto, Jun Takebe, Tatsuaki Matsubara, Keiko Naruse   +20 more
doaj   +2 more sources