Results 191 to 200 of about 835,910 (363)

Plasma prostaglandin and diabetic retinopathy

Indian Journal of Ophthalmology, 1987
Estimation of prostaglandin El (PGE) levels by bioassay technique (Ritcher Crossland) was carried out in 15 normal persons, 15 diabetic patients without Retinopathy, and 30 diabetic patients with Retinopathy.
Maurya OPS, Singh R, Bhattacharya S, Agarwal J   +3 more
doaj  

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture, 1973. [PDF]

, 1974
Nicholas J. Ashton
openalex   +1 more source

Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes

Journal of the American Medical Association (JAMA), 2017
D. Ting, C. Cheung, Gilbert Lim, G. Tan, N. Quang, A. Gan, Haslina Hamzah, R. García-Franco, Ian Yew San Yeo, S. Lee, E. Wong, C. Sabanayagam, M. Baskaran, Farah Ibrahim, N. Tan, E. Finkelstein, E. Lamoureux, I. Wong, N. Bressler, S. Sivaprasad, R. Varma, J. Jonas, M. He, Ching-Yu Cheng, G. Cheung, T. Aung, W. Hsu, M. Lee, T. Wong   +28 more
semanticscholar   +1 more source

Evaluation of the treatment effectiveness of oral and intralesional steroids in idiopathic granulomatous mastitis using superb microvascular imaging

ANZ Journal of Surgery, EarlyView.
Abstract Objectives The objective of this study was to compare the efficacy of oral and intralesional steroid injection in the treatment of idiopathic granulomatous mastitis (IGM) cases with clinical, ultrasonography (US) and Superb microvascular imaging (SMI) findings.
Oğuz Karakayalı, Yasemin Kayadibi, Berrin Papila, Seda Aladag Kurt, Gökçen Yıldız Civan, Mehmet Velidedeoglu, Mehmet Halit Yılmaz   +6 more
wiley   +1 more source

Causal association between cystatin C and diabetic retinopathy: A two‐sample Mendelian randomization study

Journal of Diabetes Investigation
Objective To explore the causal relationship between cystatin C levels and different stages of diabetic retinopathy through Mendelian randomization (MR).
Yimeng Ruan, Ping Zhang, Xiangzhe Li, Xinru Jia, Dongwei Yao   +4 more
doaj   +1 more source

Two‐year changes of macular choroidal thickness in response to 0.01% atropine eye drops: Results from the myopia outcome study of atropine in children (MOSAIC) clinical trial

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate 2‐year changes in macular choroidal thickness (ChT) in children receiving 0.01% atropine eyedrops and its relationship with spherical equivalent refraction (SER) progression and axial length (AL) elongation. Methods A total of 250 myopic children aged 6–16 years (167%–0.01% atropine, 83‐placebo) were enrolled in the ...
Emmanuel Kobia‐Acquah, Gareth Lingham, Daniel Ian Flitcroft, James Loughman   +3 more
wiley   +1 more source

Prototype master protocol for benchmarking of real‐world follow‐up data in glaucoma

Acta Ophthalmologica, EarlyView.
Abstract Purpose The purpose of this study was to create a prototype master protocol for benchmarking glaucoma real‐world data (RWD). Benchmarking is part of the digital innovation strategy of the Finnish aces‐rwm ecosystem (automation of care and evaluation of the system with real‐world monitoring).
Pekko Hujanen, Anja Tuulonen, Sanna Leinonen, Kristian Vepsäläinen, Gauti Jóhannesson, Anu Vaajanen, Eemil Lehtonen, Hannele Uusitalo‐Jarvinen   +7 more
wiley   +1 more source

Low‐contrast visual acuity versus low‐luminance visual acuity in choroideremia

Clinical and Experimental Optometry, EarlyView., 2020
Clinical relevance Choroideremia is a progressive X‐linked inherited rod‐cone dystrophy. Patients present with nyctalopia and progressive visual field loss, but visual acuity remains well preserved early on. This study showed that low‐luminance visual acuity may be a useful clinical outcome measure during earlier disease stages.
Laura J Wood, Jasleen K Jolly, Colm D Andrews, Iain R Wilson, Doron Hickey, Jasmina Cehajic‐Kapetanovic, Robert E MacLaren   +6 more
wiley   +1 more source