Results 71 to 80 of about 709 (266)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Reliability and Diagnosability Analysis of Hyper Bijective Connection Networks
IEEE Access, 2018 Bijective connection (BC) networks, including a family of interconnection networks of multiprocessor systems, have been studied extensively due to its desirable properties, such as lower diameter, high reliability, and diagnosability.
Enqiang Zhu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The Strong Local Diagnosability of a Hypercube Network with Missing Edges
Complexity, 2018 In the research on the reliability of a connection network, diagnosability is an important problem that should be considered. In this article, a new concept regarding diagnosability, called strong local diagnosability (SLD), which describes the local ...
Min Xie, Jiarong Liang, Xi Xiong
doaj +1 more source
The
IEEE Access, 2019 The connectivity and diagnosability of a system or a network are two important measures. In 1996, Fàbrega and Fiol proposed the $h$ -extra connectivity of the network $G=(V,E)$ , which is necessary for $(h,m)$ -diagnosability of networks.
Shiying Wang, Yunxia Ren
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Extra Connectivity and Extra Diagnosability of Enhanced Folded Hypercube-like Networks
MathematicsIn the design of multiprocessor systems, evaluating the reliability of interconnection networks is a critical aspect that significantly impacts system performance and functionality.
Yihong Wang, Cheng-Kuan Lin
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source