Results 111 to 120 of about 4,227,634 (314)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. [PDF]

, 2012
The prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show cognitive decline in terms of a mild cognitive impairment already in early stages that predict the development of dementia, which can occur in up to 80% of PD patients ...
Hans A Kretzschmar, Manuela Neumann, Hans A. Kretzschmar (46374), Neumann, Manuela, Soininen, H., Saskia Tawfik, Hengerer, B., Herukka, Sanna-Kaisa, Kulaksiz, H., Ferger, B., Tawfik, Saskia, Steinacker, Petra, Steinacker, P., Lenter, M., Manuela Neumann (120819), Jesse, S., Lehnert, S., Kulaksiz, Hasan, Bastian Hengerer, Neumann, M., Christine A F von Arnim, Markus Otto (120832), Otto, Markus, Christine A. F. von Arnim (120817), Lucilla Parnetti (120805), Sarah Jesse (120792), Parnetti, Lucilla, Hilkka Soininen, Jahn, Olaf, Wiltfang, Jens, Hilkka Soininen (120808), Jahn, O., Petra Steinacker (120812), Tumani, Hayrettin, Lenter, Martin, Kretzschmar, Hans A., Tumani, H., Otto, M., Boris Ferger, Hayrettin Tumani, Martin Lenter, Hengerer, Bastian, Saskia Tawfik (120814), Wiltfang, J., Olaf Jahn, Lucilla Parnetti, Soininen, Hilkka, Bastian Hengerer (120831), Sanna-Kaisa Herukka, Olaf Jahn (120801), Martin Lenter (120825), von Arnim, Christine A. F., Markus Otto, von Arnim, C., Stefan Lehnert, Petra Steinacker, Hayrettin Tumani (120815), Arnim, Christine A. F. von, Hasan Kulaksiz, Ferger, Boris, Stefan Lehnert (120797), Jens Wiltfang (44073), Sanna-Kaisa Herukka (120810), Jens Wiltfang, Kretschmar, H., Parnetti, L., Hasan Kulaksiz (120823), Boris Ferger (120827), Herukka, S., Jesse, Sarah, Tawfik, S., Lehnert, Stefan, Sarah Jesse   +72 more
core   +1 more source

Differential diagnosis diphtheria adults [PDF]

, 2014
A total of 1,824 human cases of diphtheria, treated at the Clinical Infectious Diseases Hospital SP Botkin (St. Petersburg) during 1993, as well as 19 deaths in 1994.
V. F. Krumgolts, D. A. Pavlovich, Yu. P. Finogeev, Yu. A. Vinakmen, Yu. I. Liashenko   +4 more
core   +1 more source

Overview of Differential Diagnosis

International Psychogeriatrics, 1997
Alzheimer's disease (AD) is an example of cortical dementia, where most of the pathological changes lie in cortical association areas and the predominant clinical features are symptomatic of cortical dysfunction. The differential diagnosis of AD is complex and is usually made in two stages: diagnosis of the dementia syndrome and diagnosis of the ...
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Diagnosis, differential diagnosis, and treatment for sudden sensorineural hearing loss: Current otolaryngology practices in China. [PDF]

Front Neurol, 2023
Chen N, Karpeta N, Ma X, Ning X, Liu X, Song J, Jiang Z, Ma X, Liu X, Zhong S, Sun Q, Liu J, Chen G, Duan M, Yu L.   +14 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Non-Invasive miRNA Profiling for Differential Diagnosis and Prognostic Stratification of Testicular Germ Cell Tumors

Background/Objectives: Testicular germ cell tumors (TGCT) are common in young adult men and have high cure rates. Conventional serum tumor markers and imaging are not able to differentiate between histologic subtypes of the disease, which portend ...
Ioannis Zachos, Panagiotis J. Vlachostergios, Vassilios Tzortzis, Eleni Thodou, Maria Samara, Konstantinos Evmorfopoulos, Antonis Giakountis, Konstantinos Dimitropoulos   +7 more
core   +1 more source

Tick-borne encephalitis and differential diagnosis

Annales Academiae Medicae Silesiensis
Introduction: Tick-borne encephalitis (TBE) is an infection caused by the tick-borne encephalitis virus transmitted to humans by tick bites. The prevalence of TBE is between 10,000 and 15,000 cases annually and is comparable in Europe and Asia.
Patrycja Ochman-Pasierbek, Przemysław Olczyk, Magdalena Matlakiewicz, Justyna Paprocka, Adrianna Kalinowska-Doman   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source