Results 71 to 80 of about 7,292,022 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. New and improved definition of dry eye disease (DED) emphasized that hiperosmolarity and inflammation with initial tear film instability play etiological role.
Dačić-Krnjaja Bojana, Potić Jelena, Raonić Danijela, Stojković Milenko   +3 more
doaj   +1 more source

The differential diagnosis of thrombocytopenia

Deutsches Ärzteblatt international
Thrombocytopenia is defined as a platelet count below 150 000/μL. It increases the risk of bleeding, often due to an existing underlying condition. A meticulous diagnostic evaluation is needed so that specific treatment can be initiated and complications avoided.This review is based on clinical studies up to June 2025 that were retrieved by a selective
Miesbach, Wolfgang, Stratmann, Jan, Sonja Alesci, Rosa, Chromik, Jörg, Bakchoul, Tamam, Wendt, Ralph   +5 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A young soldier with syncope, shortness of breath and palpitations [PDF]

Vojnosanitetski Pregled, 2010
Introduction. Coronary artery disease in people under 30 years is relatively uncommon, but once a disease occurs it brings a significant morbidity and psychological effects. Case report.
Mladenović Zorica, Mijailović Zdravko, Tavčiovski Dragan, Ilić Radoje, Rusović Siniša, Trifunović Zoran, Matunović Radomir   +6 more
doaj   +1 more source

Advances in Hemophagocytic Lymphohistiocytosis: Pathogenesis, Early Diagnosis/Differential Diagnosis, and Treatment

TheScientificWorldJournal, 2011
Hemophagocytic lymphohistiocytosis (HLH) is a histiocytic disorder characterized by a highly stimulated, but ineffective, immune response to antigens, which results in life-threatening cytokine storm and inflammatory reaction.
Yongmin Tang, Xiao‐jun Xu
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Pathological differential diagnosis of focal cortical dysplasia type Ⅱ and its mimic lesions

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Malformation of cortical development (MCD) accounts for the majority of drug⁃resistant epilepsy, focal cortica ldysplasia type Ⅱ (FCDⅡ) is the most common and most characteristic. It is of great significance to correct diagnosis for FCDⅡ.
Hai-nan LI, Zhi LI
doaj  

Solitary fibrous tumor: an updated review [PDF]

Journal of Pathology and Translational Medicine
Solitary fibrous tumor (SFT) is a fibroblastic neoplasm characterized by a branching, thin-walled dilated staghorn-shaped (hemangiopericytoma-like) vasculature and a NAB2::STAT6 gene fusion.
Joon Hyuk Choi
doaj   +1 more source

Left ventricular noncompaction in a patient presenting with a left ventricular failure [PDF]

Vojnosanitetski Pregled, 2018
Introduction. Left ventricular noncompaction (LVNC) is a congenital disorder characterised by prominent trabeculations in the left ventricular myocardium.
Ristić-Anđelkov Anđelka, Vraneš Danijela, Mladenović Zorica, Rusović Siniša, Ratković Nenad, Vukotić Snježana, Torbica Lidija, Milić Veljko, Mišić Tatjana, Ristić Mirjana, Baškot Branislav, Pandrc Milena   +11 more
doaj   +1 more source