Results 71 to 80 of about 4,227,634 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Severe form of Legionnaires' disease in an immunocompetent patient [PDF]

Vojnosanitetski Pregled, 2009
Background. Legionnaires' disease (LD) is a pneumonia caused by Legionella pneumophila (LP). The disease occurs more often in immunocompromised persons and can be manifested by severe pneumonia, multiple organ failure and has a high mortality.
Andrijević Ilija, Matijašević Jovan, Považan Đorđe, Kojičić Marija, Batranović Uroš   +4 more
doaj   +1 more source

Ejaculate in Differential Diagnosis [PDF]

Deutsches Ärzteblatt international, 2012
It is perhaps worth mentioning that examination of ejaculate can be helpful in the diagnosis of men with bronchiectasis of unknown origin: if they have cystic fibrosis, these patients usually have azoospermia, but unlike patients with Klinefelter syndrome they usually have testes of normal size.
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pathological differential diagnosis of focal cortical dysplasia type Ⅱ and its mimic lesions

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Malformation of cortical development (MCD) accounts for the majority of drug⁃resistant epilepsy, focal cortica ldysplasia type Ⅱ (FCDⅡ) is the most common and most characteristic. It is of great significance to correct diagnosis for FCDⅡ.
Hai-nan LI, Zhi LI
doaj  

Solitary fibrous tumor: an updated review [PDF]

Journal of Pathology and Translational Medicine
Solitary fibrous tumor (SFT) is a fibroblastic neoplasm characterized by a branching, thin-walled dilated staghorn-shaped (hemangiopericytoma-like) vasculature and a NAB2::STAT6 gene fusion.
Joon Hyuk Choi
doaj   +1 more source

Differential Diagnosis of Parkinsonism [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1999
The diagnosis of Parkinson's disease is predominantly clinical, based on a combination of the cardinal features of tremor, bradykinesia and rigidity. The differential essentially lies between other conditions resulting in tremor, of which essential tremor is the commonest, and other akinetic-rigid syndromes. These include progressive supranuclear palsy,
A J, Stoessl, J, Rivest
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Increased Toll-like receptor 9 expression associated with cellular proliferation and poor prognosis in pleural mesothelioma [PDF]

Journal of Pathology and Translational Medicine
Background Pleural mesothelioma is an aggressive malignancy with a poor prognosis. The epithelioid subtype is the most common and can be challenging to distinguish from metastatic lung adenocarcinoma (MLAC). The role of Toll-like receptor 9 (TLR9) in the
Ali Omar Abdelaziz, Dina Moustafa Thabit, Rehab Mohamed Kamal, Hend Moness, Rasha Fouad Ahmed, Mariana Fathy Gayyed, Fatma El Zahraa Ammar Mohamed   +6 more
doaj   +1 more source

Neutrophil myeloperoxidase index in pediatric acute appendicitis [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Diagnosis of acute appendicitis (AA) remains the most common dilemma of pediatric surgical team. Our aim was to determine whether the neutrophil myeloperoxidase index (MPXI), in combination with other laboratory and clinical parameters ...
Stanković Nikola, Đorđević Dragan, Rondović Goran, Kostić Zoran, Zeba Snježana, Milosavljević Snežana, Savić Đorđe, Miličković Maja, Grujić Blagoje, Đuričić Slaviša, Milanović Marijana, Stanojević Ivan   +11 more
doaj   +1 more source