Results 51 to 60 of about 747,888 (257)

Treatment of Dual Diagnosis in Denmark

Qualitative Studies, 2018
Treatment for dual diagnosis in Denmark is divided between a medically based psychiatric treatment system and a socially oriented substance use treatment system; consequently, in order to deliver the most effective treatment to people with dual diagnosis,
Katrine Schepelern Johansen
doaj   +1 more source

What Can Quantitative Gait Analysis Tell Us about Dementia and Its Subtypes? A Structured Review [PDF]

, 2017
Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia.
Galna, Brook, Mc Ardle, Ríona, Morris, Rosie, Rochester, Lynn, Thomas, Alan J., Wilson, Joanna   +5 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Barriers to linkage to care in hepatitis C patients with substance use disorders and dual diagnoses, despite centralized management

Therapeutic Advances in Gastroenterology, 2021
Background: Hepatitis C virus (HCV) management is a challenge in patients with substance use disorder (SUD). This study aimed to describe an HCV screening and linkage to care program in SUD patients, and analyze the characteristics of this population in ...
Lara Grau-López, Cristina Marcos-Fosch, Constanza Daigre, Raúl Felipe Palma-Alvarez, Ariadna Rando-Segura, Jordi Llaneras, Marta Perea-Ortueta, Francisco Rodriguez-Frias, Nieves Martínez-Luna, Mar Riveiro-Barciela, Josep Antoni Ramos-Quiroga, Joan Colom, Rafael Esteban, María Buti   +13 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Predicting costs of mental health care: a critical literature review [PDF]

, 2007
Cost evaluation research in the mental health field is being increasingly recognized as a way to achieve a more effective deployment of scarce resources.
Amaddeo, F., Barbui, C., Jones, J., Tansella, M.   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Psychosocial interventions in patients with dual diagnosis

Indian Journal of Psychiatry, 2019
Management of patients with dual diagnosis (Mental illness and substance use disorders) is a challenge. A lack of improvement in either disorder can lead to a relapse in both.
B.N Subodh, Nidhi Sharma, Raghav Shah
doaj   +1 more source