Results 141 to 150 of about 2,850,943 (269)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Role of Generative Artificial Intelligence in the Diagnosis and Treatment of Malocclusion. [PDF]

Cureus
Alsayed NA.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Challenges in the Diagnosis and Treatment of Mycobacterium abscessus Infections. [PDF]

Rev Soc Bras Med Trop
Reis AJ, Gómez MAA, Souza MQ, Vianna JS, Ramis IB, Silva PEAD.   +5 more
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

<i>Legionellosis</i>: Global Epidemiology and Current Perspectives on Diagnosis and Treatment. [PDF]

Infect Drug Resist
Ma J, Dong T, Li F, He C, Li B, Liu Z.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Clinical Practice Guidelines on the Diagnosis and Treatment of Halitosis. [PDF]

Int Dent J
Shang X, Chen X, Lv C, Wang Z, Chen B, Shao J, Liang Y, Song A, Guo H, Yu Y, Liu H, Du M, Zhang J, Kang W, Li J, Ma B, Yan F, Pan Y, Chen F, Xu Y, Luan Q, Zhao L, Sun Y, Song Z, Liu Y, Cao Z, Xia J, Zhao C, Li A, Sun J, Wang Z, Luo L, Ren X, Xu S, Ma D, Xie Y, Zhu G, Zhong L, Lin J, Chen F, Peng X, Li X, Ding P, Xu J, Luo K, Li A, Lin L, Tian B, Chen Y, Li X, Feng Q, Deng J, Yuan C, Ding G, Zhu H, Pan K, Wang X, Qiu C, Ren G, Liu M, Sun X, Ge S, Zhang R, Li L, Lu S, Tian T, Chen Q, Wang H, Wang D, Wang X, Zhang C, Zhou X, Ge S.   +72 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Diagnosis and Treatment of Ectopic Pregnancy in a Cesarean Section Scar-Case Report. [PDF]

J Clin Med
Kulabukhova PV, Fokina TV, Babaeva MN, Asaturova AV, Nizyaeva NV.   +4 more
europepmc   +1 more source