Results 101 to 110 of about 986,235 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Identifying Disease of Interest With Deep Learning Using Diagnosis Code. [PDF]

J Korean Med Sci, 2023
Cho YS, Kim E, Stafford PL, Oh MH, Kwon Y.   +4 more
europepmc   +1 more source

Under-reporting of roadcasualties ? phase 1 [PDF]

, 2006
Although this report was commissioned by the Department for Transport, the findings and recommendations are those of the authors and do not necessarily represent the views of the ...
Lyons, R, Thoreau, R, Ward, H
core  

Dipole: Diagnosis Prediction in Healthcare via Attention-based Bidirectional Recurrent Neural Networks

, 2017
Predicting the future health information of patients from the historical Electronic Health Records (EHR) is a core research task in the development of personalized healthcare.
Ba Jimmy, Cheng Yu, Choi Edward, Lipton Zachary C, Suo Qiuling, Wang Xiang, Xu Kelvin, Zeiler Matthew D   +7 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Validation of human immunodeficiency virus diagnosis codes among women enrollees of a U.S. health plan

BMC Health Services Research
Background Efficiently identifying patients with human immunodeficiency virus (HIV) using administrative health care data (e.g., claims) can facilitate research on their quality of care and health outcomes.
Gaia Pocobelli, Malia Oliver, Ladia Albertson-Junkans, Gabrielle Gundersen, Aruna Kamineni   +4 more
doaj   +1 more source

Diagnosis Code and Health Care Utilization Patterns Associated With Diagnostic Uncertainty. [PDF]

Hosp Pediatr, 2022
Marshall TL, Hagedorn PA, Sump C, Miller C, Fenchel M, Warner D, Ipsaro AJ, O'Day P, Lingren T, Brady PW.   +9 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Leveraging a New ICD-10 Diagnosis Code to Characterize Hospitalized Patients With Primary Sclerosing Cholangitis. [PDF]

Clin Gastroenterol Hepatol, 2023
Wang M, Auerbach A, Oreper SM, Hohmann SF, Lai JC, Rubin JB.   +5 more
europepmc   +1 more source