Results 181 to 190 of about 4,179,888 (309)

Diagnostic Pneumoperitoneum [PDF]

Gastroenterologia, 1955
S C, TRUELOVE, K, LUMSDEN
openaire   +4 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Rare diseases in Brazil: a nationwide analysis of the diagnostic odyssey. [PDF]

J Community Genet
de Oliveira BM, Broch MS, de Oliveira CP, Piovesana A, Lorea CF, Scortegagna ML, Fighera GZ, Viegas I, Barp LP, Alonso M, Vergara A, Martins AM, Grumach AS, Acosta AX, Ribeiro BFR, Ramos CF, Grangeiro CHP, Kim CA, Melo DG, Michelatto D, Christofolini D, Carvalho EDF, Ribeiro EM, Serpa FS, Brandão FR, Monlleó IL, Oliveira JA, Llerena JC, Donis KC, Giuliani LR, Pinto LLC, da Silva LCS, Costa MCM, Galera MF, Giusti MMCG, Santos MLSF, de Andrade MDFC, Cardoso MTO, Caldato MCF, Pereira NG, Boa Sorte N, de Medeiros PFV, Zen PRG, da Silva RTB, Maia RE, Kyosen SO, Valle S, Amorim T, Teixeira TB, Prazeres VMG, de Faria Ferraz VE, Schwartz IVD, Alves D, Félix TM, Raras Network Group.   +54 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Gadopiclenol Breast MRI With Half Standard Gadolinium Dose Maintains High Parenchymal Contrast in Intraindividual Comparison. [PDF]

Invest Radiol
Gruschwitz P, Richter K, Meir M, Schlaiß T, Grunz JP, Schömig SA, Pichlmeier S, Bley TA, Sauer ST.   +8 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A strategic roadmap for the Diagnostic and Scientific Manual (DSM) of mental disorders. [PDF]

World Psychiatry
Oquendo MA, Alpert JE, Yousif L, Gogtay N, Clarke DE.   +4 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Diagnosis of Benign Paroxysmal Positional Vertigo: Review of Different Diagnostic Methods. [PDF]

Audiol Res
Shestel EA, Burtsev DV, Zubanov PS, Goldberg AS, Tregub PP.   +4 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source