Results 51 to 60 of about 786,796 (264)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials

Nature Communications
Clinical trials demonstrate that screening can reduce lung cancer mortality by over 20%. However, lung cancer screening effectiveness (reduction in lung cancer specific mortality) may vary by personal risk-factors.
Max Welz, Carlijn M. van der Aalst, Andreas Alfons, Andrea A. Naghi, Marjolein A. Heuvelmans, Harry J. M. Groen, Pim A. de Jong, Joachim Aerts, Matthijs Oudkerk, Harry J. de Koning, Kevin ten Haaf, On behalf of the NELSON trial consortium   +11 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Comparison of medic and 3D DESS with routine MRI to assess the diagnostic efficacy in symptomatic temporomandibular disorders: a cross sectional observational study

Scientific Reports
Temporomandibular disorders (TMDs) involve functional and structural disturbances of the temporomandibular joint (TMJ), often requiring early imaging for effective management.
Elakya Ramesh, Anuradha Ganesan, Jeevitha Gauthaman, Krithika Chandrasekar Lakshmi, Saravanan Kannan   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Cost–effectiveness of lung cancer screening with volume computed tomography in Portugal

Journal of Comparative Effectiveness Research
Aim: Lung cancer is the most common cause of cancer death in Portugal. The Dutch–Belgian lung cancer screening (LCS) study (NELSON), the biggest European LCS study, showed a lung cancer mortality reduction in a high-risk population when being screened.
Hilde ten Berge, Katerina Togka, Xuanqi Pan, Marina Borges, Fernando Palma Martelo, Fernando Guedes, Daniel Cabral, Encarnacao Teixeira, Gabriela Fernandes, Lurdes Ferreira, Sara Figueiredo, Rita Sousa, Lourdes Barradas, Fernanda Estevinho, Antonio Araujo, Venceslau Hespanhol, Rui Medeiros   +16 more
doaj   +1 more source

Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

Alzheimer’s Research & Therapy
Background The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI).
Alberto Benussi, Enrico Premi, Mario Grassi, Antonella Alberici, Valentina Cantoni, Stefano Gazzina, Silvana Archetti, Roberto Gasparotti, Giorgio G. Fumagalli, Arabella Bouzigues, Lucy L. Russell, Kiran Samra, David M. Cash, Martina Bocchetta, Emily G. Todd, Rhian S. Convery, Imogen Swift, Aitana Sogorb-Esteve, Carolin Heller, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Fermin Moreno, Robert Jr. Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre Mendonça, Pietro Tiraboschi, Chris R. Butler, Isabel Santana, Alexander Gerhard, Isabelle Le Ber, Florence Pasquier, Simon Ducharme, Johannes Levin, Sandro Sorbi, Markus Otto, Alessandro Padovani, Jonathan D. Rohrer, Barbara Borroni, Genetic Frontotemporal dementia Initiative (GENFI)   +47 more
doaj   +1 more source

Chinical Diagnostic accarcy of basal cell carcinoma of the periorbital region [PDF]

Journal of Mazandaran University of Medical Sciences, 2005
Background and purpose : Basal cell carcinoma is the most common malignancy of the eyelids and is frequently misdiagnosed.Materials and methods : The diagnostic accuracy and index of suspicion of basal cell carcinoma of the periorbital region for ...
S. Saryazdi, M.R. Meshkat
doaj