Results 51 to 60 of about 4,265,853 (264)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Lung cancer screening in Lithuania: a cost-effectiveness analysis

Journal of Comparative Effectiveness Research
Aim: This study aimed to assess the cost-effectiveness of the annual volumetric-enabled low-dose computed tomography (LDCT) lung cancer screening (LCS), based on the NELSON screening outcomes, versus no screening for the asymptomatic high-risk ...
Hilde ten Berge, Greta Piazza, Dianne Ramaker, Xuanqi Pan, Titas Buksnys, Saulius Cicėnas, Skaidrius Miliauskas, Giedre Smailyte, Rolandas Zablockis, Marius Zemaitis, Edvardas Danila   +10 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Facilitating Prospective Registration of Diagnostic Accuracy Studies: A STARD Initiative [PDF]

, 2017
Although the introduction of prospective trial registration policies has been successful in reducing waste in research, diagnostic accuracy studies are rarely registered. We describe why diagnostic accuracy studies should be registered, and where and how
Constantine A Gatsonis, Faure, Hélène, Bossuyt, Patrick M., Patrick M M Bossuyt, Lotty Hooft, Jérémie F Cohen, Rifai, Nader, Matthew D F McInnes, Hooft, Lotty, Daniël A Korevaar, Kressel, Herbert Y., Moher, David, Cohen, Jérémie F., Hunter, Kylie E., Herbert Y Kressel, Virginia Barbour, Gatsonis, Constantine A., Kylie E Hunter, Lisa M Askie, Askie, Lisa M., Korevaar, Daniël A., McInnes, Matthew D., David Moher, Lippman, Hannah, Hélène Faure, Hannah Lippman, Barbour, Virginia, Nader Rifai   +27 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A PROSPECTIVE STUDY ON EVALUATION OF DIAGNOSTIC PERFORMANCE OF GENEXPERT MTB IN CSF FOR EARLY DIAGNOSIS OF TUBERCULAR MENINGITIS IN A TERTIARY CARE HOSPITAL ODISHA.

Student's Journal of Health Research Africa, 2023
Aim The study aims to establish the diagnostic accuracy of GeneXpert MTB/RIF in CSF for early diagnosis of tubercular meningitis and to compare the efficacy of CSF GeneXpert MTB/RIF with CSF culture for mycobacterium.
Aditya Narayan Sahu, Asit Kumar Mallick, Suman Kumar Jagaty, Saswat Subhankar, Debasis Behera, Sankarsan Das   +5 more
doaj  

Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies. [PDF]

, 2013
Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency.
Kerkhoff, Andrew D, Dorman, Susan, Peter, Jonathan, Nicol, Mark, Catharina C Boehme, Peter, Jonathan G, Boehme, Catharina C, Kerkhoff, Andrew, Nicol, Mark P, Keertan Dheda, Peter, Jonathan G., Lawn, Stephen, Lawn, Stephen D., Kerkhoff, Andrew D., Lawn, Stephen D, Dheda, Keertan, Mark P Nicol, Andrew D Kerkhoff, Nicol, Mark P., Jonathan G Peter, Boehme, Catharina, Stephen D Lawn, Susan Dorman, Boehme, Catharina C.   +23 more
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Viral Hepatitis and Rapid Diagnostic Test Based Screening for HBsAg in HIV-infected Patients in Rural Tanzania. [PDF]

, 2013
\ud \ud Co-infection with hepatitis B virus (HBV) is highly prevalent in people living with HIV in Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg) before initiation of combination antiretroviral therapy (cART) is recommended. However, it is
Emilio Letang, Mwaigomole, Geoffrey, Battegay, Manuel, Lars Henning, Abdul, Omary, Marcel Tanner, Hatz, Christoph, Ngwale, Ramadhani, Franzeck Fabian C., Henning, Lars, Geoffrey Mwaigomole, Ramadhani Ngwale, Marian Hamisi, Tanner, Marcel, Omary Abdul, Ngwale Ramadhani, Hamisi, Marian, Mwaigomole Geoffrey, Bernadeta Msongole, Henning Lars, Tanner Marcel, Franzeck, Fabian C., Manuel Battegay, Msongole Bernadeta, Fabian C Franzeck, Fabian C. Franzeck, Msongole, Bernadeta, Letang, Emilio, Hamisi Marian, Hatz Christoph, Letang Emilio, Battegay Manuel, Christoph Hatz, Franzeck, Fabian C, Abdul Omary   +34 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source