Results 61 to 70 of about 4,265,853 (264)

Collective Intelligence Increases Diagnostic Accuracy in a General Practice Setting. [PDF]

BACKGROUND General practitioners (GPs) work in an ill-defined environment where diagnostic errors are prevalent. Previous research indicates that aggregating independent diagnoses can improve diagnostic accuracy in a range of settings.
Kurvers, Ralf H J M, Kämmer, Juliane E, Herzog, Stefan M., Zoeller, Nikolas, Kurvers, Ralf H. J. M., Kurvers, Ralf HJM, Kämmer, Juliane E., Herzog, Stefan M, Kaemmer, Juliane E, Blanchard, Matthew D., Blanchard, Matthew D, Zöller, Nikolas, Kostopoulou, Olga   +12 more
core   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands. [PDF]

, 2008
BACKGROUND: The accuracy of malaria diagnosis has received renewed interest in recent years due to changes in treatment policies in favour of relatively high-cost artemisinin-based combination therapies.
Kristan, Mojca, Cox, Jonathan, Michael Okia, Jones Caroline, James Beard, Beard, James, Okia Michael, Caroline Jones, Jones, Caroline, Greenwood, Brian, Brian Greenwood, Rapuoda, Beth, Abeku Tarekegn A, Kristan Mojca, Cox Jonathan, Mojca Kristan, Mueller Dirk H, Dirk H Mueller, Greenwood Brian, Beth Rapuoda, Mueller, Dirk H, Tarekegn A Abeku, Rapuoda Beth, Jonathan Cox, Abeku, Tarekegn A, Okia, Michael, Beard James   +26 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study [PDF]

, 2014
Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection.
Jonny Peter, Greg Symons, Meldau, Richard, Symons, Greg, Calligaro, Greg, van Zyl-Smit, Richard, Gina Ntombenhle, Peter, Jonny, Hoosain Khalfey, Keertan Dheda, Grant Theron, Greg Calligaro, Brian Allwood, Anke Binder, Allwood, Brian, Govender, Ureshnie, Ntombenhle, Gina, Ureshnie Govender, Dheda, Keertan, Theron, Grant, Khalfey, Hoosain, Richard Meldau, Richard van Zyl-Smit, Binder, Anke   +23 more
core   +2 more sources

Diagnostic Accuracy of Point-of-Care Ultrasound for Intussusception: A Multicenter, Noninferiority Study of Paired Diagnostic Tests

, 2021
Study objective: To determine the diagnostic accuracy of point-of-care ultrasound (POCUS) performed by experienced clinician sonologists compared to radiology-performed ultrasound (RADUS) for detection of clinically important intussusception, defined as ...
Tessaro, Mark O, Bergmann, Kelly R, Arroyo, Alexander C, Chaudoin, Lindsey, Nielson, Jonathan, Deanehan, J Kate, Yock-Corrales, Adriana, Whitcomb, Valerie, Madhok, Manu, Berant, Ron, Snelling, Peter J, Guerrero-Quesada, German, Shahar-Nissan, Keren, Lam, Samuel HF, et al.   +14 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials

Nature Communications
Clinical trials demonstrate that screening can reduce lung cancer mortality by over 20%. However, lung cancer screening effectiveness (reduction in lung cancer specific mortality) may vary by personal risk-factors.
Max Welz, Carlijn M. van der Aalst, Andreas Alfons, Andrea A. Naghi, Marjolein A. Heuvelmans, Harry J. M. Groen, Pim A. de Jong, Joachim Aerts, Matthijs Oudkerk, Harry J. de Koning, Kevin ten Haaf, On behalf of the NELSON trial consortium   +11 more
doaj   +1 more source