Results 61 to 70 of about 1,570,944 (351)

A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials

Nature Communications
Clinical trials demonstrate that screening can reduce lung cancer mortality by over 20%. However, lung cancer screening effectiveness (reduction in lung cancer specific mortality) may vary by personal risk-factors.
Max Welz, Carlijn M. van der Aalst, Andreas Alfons, Andrea A. Naghi, Marjolein A. Heuvelmans, Harry J. M. Groen, Pim A. de Jong, Joachim Aerts, Matthijs Oudkerk, Harry J. de Koning, Kevin ten Haaf, On behalf of the NELSON trial consortium   +11 more
doaj   +1 more source

Diagnostic accuracy of TB-LAMP for pulmonary tuberculosis: a systematic review and meta-analysis. [PDF]

, 2019
BACKGROUND:The need for a rapid, molecular test to diagnose tuberculosis (TB) has prompted exploration of TB-LAMP (Eiken; Tokyo, Japan) for use in resource-limited settings.
Cattamanchi, Adithya, Farr, Katherine, Gray, Christen M, Shete, Priya B, Strnad, Luke   +4 more
core   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Diagnostic Accuracy of Home Sleep Apnea Testing (HSAT) Based on Recording Duration [PDF]

, 2019
Introduction: Obstructive Sleep Apnea (OSA) is a chronic sleeping disorder with serious health consequences. Currently, standard diagnosis is through in-lab polysomnography; however, there has been a shift to greater use of Home Sleep Apnea Testing (HSAT)
Alnemri, Angela, Doghramji, Karl, Fynn, Theodora, Grewa, Ritu, Vasudevan, Prakash   +4 more
core   +1 more source

The 10-word learning task in the differential diagnosis of early Alzheimer's disease and elderly depression: a cross-sectional pilot study [PDF]

, 2010
Objectives: Identification of early Alzheimer's disease (AD) has become very important. Episodic memory tasks appear to have predictive power for indicating early AD. Deficits in encoding and storage processes that are characteristic of AD, however, must
D'Haenens, Ellen, De Deyn, Peter Paul, De Raedt, Rudi, Dierckx, Eva, Engelborghs, Sebastiaan, Ponjaert-Kristoffersen, Ingrid, Verte, Dominique   +6 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Diagnostic Accuracy of Urinary Spot Protein: Creatinine Ratio Versus 24 hours urinary Proteins in Patients with Preeclampsia [PDF]

, 2021
Abdou Saeed Ait-Allah, Hany Farouk, Abd El-Rahman, Hassan Al-Jamily, Hassan Saleh, J Waugh, S Bell, M Kilby, C Blackwell, P Seed, S Amin, S Illipilla, M Pai, J Park, D Chung, H Cho, Y Kim, G Son, S Jan, C Javaid, N Firdous, J Eigbefoh, J Abebe, P Isabu, N Obeid, O' Kelly, R, Abu Saadeh, F Crowley, F Daly, S, P Shrestha, H Nipanal, S Sushmitha, S Shah, P Sulthana   +35 more
openalex   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evaluation Of Quality Of Diagnostic Accuracy Studies: Turkish Adaptation Of STARD Criteria

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2012
Aim:The aim of this study is translate the STARD (The STAndards for Reporting of Diagnostic Accuracy) criteria which were developed in 2003 by a group of epidemiologists and biostatisticians in order to establish a standard for planning and reporting the
Yasemin Genç, Rabia Albayrak, Can Ateș, Mustafa Agah Tekindal, Pınar Selvi, Sibel Perçinel, Koray Ceyhan   +6 more
doaj   +1 more source

Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve [PDF]

, 2017
Background—Contrast fractional flow reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is more accurate than resting indices and does not require adenosine.
Berry, Colin, Choi, Dong-Hyun, De Bruyne, Bernard, Fearon, William F., Gould, K. Lance, Jeremias, Allen, Johnson, Nils P., Kobayashi, Yuhei, Nishi, Takeshi, Oldroyd, Keith G., Pijls, Nico H.J.   +10 more
core   +1 more source