Results 61 to 70 of about 1,517,013 (303)

Development and validation of a new glaucoma screening test using temporally modulated flicker [PDF]

, 2018
Purpose Describing the psychometric characteristics and diagnostic accuracy of the Accelerator 4‐Alternative Forced‐Choice Flicker Test prototype (A4FTp) for detecting chronic open angle glaucoma (COAG).
Ctori, I., Fidalgo, B., Jindal, A., Lawrenson, J., Tyler, C. W.   +4 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Validation of the German Revised Addenbrooke's Cognitive Examination for Detecting Mild Cognitive Impairment, Mild Dementia in Alzheimer's Disease and Frontotemporal Lobar Degeneration [PDF]

, 2010
Background/Aims: The diagnostic accuracy of the German version of the revised Addenbrooke's Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI), mild dementia in Alzheimer's disease (AD) and mild dementia in frontotemporal lobar ...
Aguilar, C. A., Alexopoulos, P., Danek, Adrian, Diehl-Schmid, J., Ebert, A., Foerstl, H., Gourzis, P., Kneib, T., Kornhuber, J., Kurz, A., Natale, B., Perneczky, R., Richter-Schmidinger, T., Schoell, E., Weih, M.   +14 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Predictive validity of the Short-Term Assessment of Risk and Treatability (START) for multiple adverse outcomes:the effect of diagnosis [PDF]

, 2017
The Short-Term Assessment of Risk and Treatability (START) assists risk assessment for seven risk outcomes based on scoring of risk and protective factors and assignment of clinically-informed risk levels.
Dickens, Geoffrey L, Marriott, Rebecca, O'Shea, Laura E, Picchioni, Marco M   +3 more
core   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Diagnostic Accuracy of Home Sleep Apnea Testing (HSAT) Based on Recording Duration [PDF]

, 2019
Introduction: Obstructive Sleep Apnea (OSA) is a chronic sleeping disorder with serious health consequences. Currently, standard diagnosis is through in-lab polysomnography; however, there has been a shift to greater use of Home Sleep Apnea Testing (HSAT)
Alnemri, Angela, Doghramji, Karl, Fynn, Theodora, Grewa, Ritu, Vasudevan, Prakash   +4 more
core   +1 more source

Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis [PDF]

, 2005
Background Ultrasound (US) has largely replaced contrast venography as the definitive diagnostic test for deep vein thrombosis (DVT). We aimed to derive a definitive estimate of the diagnostic accuracy of US for clinically suspected DVT and identify ...
A Cogo, A Cogo, A Elias, A Elias, A Gongolo, A Markel, A Miselli, AF Aburahma, AG Aitken, AJ Comerota, AJ Comerota, AJ Sutton, Alex Sutton, AT Irvine, AW Lensing, B Kassai, B van Ramshorst, B Wolf, BD Lewis, BG Birdwell, BG Birdwell, BN Raghavendra, BS Hwang, C Kearon, C Savy-Stortz, D Becker, D Cavaye, D Gaitini, DA Kristo, DC Mitchell, DH O'Leary, DL Rollins, DP Flanigan, DR Anderson, E Bernardi, E Kalodiki, Edwin van Beek, EK Yucel, F Dany, F Pasquariello, FC Sampson, Fiona Sampson, FJ Song, G Guazzaloca, GJ Zhang, GM Baxter, GM Baxter, GP Shields, GP Size, GR Simons, GV Belcaro, H Bounameaux, H Heijboer, H Heijboer, H Rosier, HJ Aronen, HO Leven, I Baumgartner, J De Laveaucoupet, J Howe, J Yao, J Zamora, JC De Valois, JE George, JE George, JF Chance, JG Lijmer, JJ Cranley, JJ Cronan, JJ Deeks, JM Schindler, JP Carpenter, JP Fletcher, JP Laissy, JPJ Archie, JS Ginsberg, K Forbes, K Ouriel, K Walsh, LA Killewich, LW Tick, M Atri, M Dauzat, M Grobety, M Hay, M Mantoni, M Monreal, M Sluzewski, MA Amin, MA Mattos, MCG Holmes, ME McCandless, MJ Bradley, MK Eskandari, MK Zhou, N Labropoulos, N Miller, NH Rosner, OM Pedersen, P De Faucal, P Vogel, PJ Bendick, PL Robertson, PL Robertson, PR Biondetti, PS Wells, PS Wells, PS Wells, PS Wells, PS Wells, PT Appelman, PT Kennedy, R Lindqvist, R Mani, R Poti, R Puls, R Quintavalla, RA Bucek, RA Kraaijenhagen, RB Patterson, SC Rose, SG Thompson, SJ Theodorou, SM Bates, SM Schellong, SM Stevens, Steve Goodacre, Steve Thomas, SW Heim, TE Gudmundsen, TL Turnbull, W Habscheid, W Wysokinski, WD Foley   +133 more
core   +5 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source