Results 131 to 140 of about 6,529,585 (334)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Mind the overlap: how system problems contribute to cognitive failure and diagnostic errors

Diagnosis, 2018
Background Traditionally, research has examined systems- and cognitive-based sources of diagnostic error as individual entities. However, half of all errors have origins in both domains.
Ashwin Gupta, M. Harrod, M. Quinn, Milisa Manojlovich, K. Fowler, Hardeep Singh, S. Saint, V. Chopra   +7 more
semanticscholar   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The most common errors in automatic ECG interpretation

Frontiers in Physiology
IntroductionThe 12-lead electrocardiogram (ECG) is one of modern medicine’s most important and useful diagnostic tests. It is a non-invasive, widely available and relatively cheap method used mainly in the diagnostics of arrhythmias and a variety of ...
Krzysztof Kraik, Krzysztof Kraik, Irena Anna Dykiert, Irena Anna Dykiert, Joanna Niewiadomska, Joanna Niewiadomska, Marta Ziemer-Szymańska, Karolina Mikołajczak, Karolina Mikołajczak, Mikołaj Kreń, Mikołaj Kreń, Piotr Kukiełka, Piotr Kukiełka, Adrian Martuszewski, Adrian Martuszewski, Tomasz Harych, Rafał Poręba, Paweł Gać, Małgorzata Poręba   +18 more
doaj   +1 more source

Correlations Between the Autolytic Changes and Postmortem Interval in Refrigerated Cadavers

Romanian Journal of Internal Medicine, 2016
Introduction. In forensic pathology the autolytic process has been observed and documented in order to determine the postmortem interval as accurately as possible. The observation and experiments have been carried out on cadavers exposed to environmental
Cocariu Ela Andra, Mageriu V., Stăniceanu Florica, Bastian Alexandra, Socoliuc C., Zurac Sabina   +5 more
doaj   +1 more source

The impact of systematic uncertainties in stellar parameters on integrated spectra of stellar populations

, 2009
In this paper we investigate a hitherto unexplored source of potentially significant error in stellar population synthesis (SPS) models, caused by systematic uncertainties associated with the three fundamental stellar atmospheric parameters; effective ...
Alonso, Bruzual, Cenarro, Maurizio Salaris, Percival, Pietrinferni, Ramírez, Schiavon, Schiavon, Schiavon, Schiavon, Susan M. Percival, Trager, Trager, Vazdekis, Vázquez, Worthey   +16 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Diagnostic error reduction in the United States and Italy through the intervention of diagnostic management teams [PDF]

, 2018
A major challenge to most countries is the growing cost of healthcare. The cost of laboratory testing is approximately 3% of the total clinical costs.
Adriana Berumen Velazquez, Michael Laposata, Roberto Verna   +2 more
core