Results 111 to 120 of about 6,529,585 (334)

The Diagnostic Performance Feedback “Calibration Gap”: Why Clinical Experience Alone Is Not Enough to Prevent Serious Diagnostic Errors

AEM Education and Training, 2018
Medical diagnostic errors can be thought of as the bottom of the iceberg of patient safety—a hidden yet vast source of morbidity and mortality. According to the U.S.
R. Omron, Susrutha Kotwal, B. Garibaldi, D. Newman-Toker   +3 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Developing a Questionnaire to Investigate Monthly Human Errors Among Railway Traffic Control Room Employees [PDF]

Iranian Rehabilitation Journal
Objectives: The working situation of railway traffic control rooms (RTCR) employees makes them susceptible to human error. On the other hand, the occurrence of human error by these staff can lead to catastrophic events.
Soleiman Ramezanifar, Ali Askari, Mohsen Porsadeghin, Mahshid Namdari, Ali Salehi Sahlabadi   +4 more
doaj  

Determining diagnostic delays in Romanian multiple myeloma patients using the Aarhus statement

Frontiers in Medicine
IntroductionMultiple Myeloma (MM) is classified as one of the most challenging cancers to diagnose, and the hematological malignancy is associated with prolonged diagnostic delays.
Ruxandra Irimia, Sorina Badelita, Sinziana Barbu, Sinziana Barbu, Ioana Loredana Cirlan, Larisa Zidaru, Daniel Coriu, Daniel Coriu   +7 more
doaj   +1 more source

Diagnostic Efficacy of Morphological Characters of Larval \u3ci\u3eTramea Lacerata\u3c/i\u3e Hagen and \u3ci\u3eTramea Onusta\u3c/i\u3e Hagen (Odonata: Libellulidae) in the Prairie Region of Missouri [PDF]

, 2018
Distinguishing among species of larvae of the dragonfly genus Tramea historically has been problematic, largely due to conflicting characterizations of the larvae of T. lacerata Hagen and T. onusta Hagen (Odonata: Libellulidae) in the literature.
Landwer, Brett H. P, Sites, Robert W
core   +2 more sources

Diagnostic errors by medical students: results of a prospective qualitative study

BMC Medical Education, 2017
BackgroundDiagnostic errors occur frequently in daily clinical practice and put patients’ safety at risk. There is an urgent need to improve education on clinical reasoning to reduce diagnostic errors.
Leah T. Braun, L. Zwaan, J. Kiesewetter, M. Fischer, R. Schmidmaier   +4 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Diagnostic errors in fatal medical malpractice cases in Shanghai, China: 1990–2015

Diagnostic Pathology, 2019
BackgroundMedical disputes remain unabated in China. Previous studies have shown the changes of diagnostic discrepancy over time in developed countries, but diagnostic discrepancy remains understudied in China, especially in the setting of medical ...
Pan Gao, Xiaoqiang Li, Ziqin Zhao, Nong Zhang, Kaijun Ma, Liliang Li   +5 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source