Results 101 to 110 of about 2,583,146 (294)

Prescribing errors : what’s the story? [PDF]

, 2001
Although prescribing errors are one of the most common causes of preventable iatrogenic injury, there have been relatively few studies of their incidence and causes. The majority of the studies that have been carried out have been based in secondary care.
Dean, Bryony
core  

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Diagnostic errors in older patients: a systematic review of incidence and potential causes in seven prevalent diseases

, 2016
Thomas R Skinner,1 Ian A Scott,2,3 Jennifer H Martin3,4 1Department of Internal Medicine, Sunshine Coast Health Service District, Nambour Hospital, Nambour, QLD, Australia; 2Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital ...
Scott IA, Martin JH, Skinner TR
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The most common errors in automatic ECG interpretation

Frontiers in Physiology
IntroductionThe 12-lead electrocardiogram (ECG) is one of modern medicine’s most important and useful diagnostic tests. It is a non-invasive, widely available and relatively cheap method used mainly in the diagnostics of arrhythmias and a variety of ...
Krzysztof Kraik, Krzysztof Kraik, Irena Anna Dykiert, Irena Anna Dykiert, Joanna Niewiadomska, Joanna Niewiadomska, Marta Ziemer-Szymańska, Karolina Mikołajczak, Karolina Mikołajczak, Mikołaj Kreń, Mikołaj Kreń, Piotr Kukiełka, Piotr Kukiełka, Adrian Martuszewski, Adrian Martuszewski, Tomasz Harych, Rafał Poręba, Paweł Gać, Małgorzata Poręba   +18 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Twelve tips for teaching avoidance of diagnostic errors.

, 2008
BACKGROUND: Despite an increasing emphasis on patient safety on the part of healthcare systems worldwide, diagnostic error remains common. Errors frequently result in significant clinical consequences and persist despite remarkable advances in diagnostic
Trowbridge, Robert L
core   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Analysing false‐positive errors when Australian radiographers use preliminary image evaluation

Journal of Medical Radiation Sciences
Introduction Diagnostic errors in the emergency departments can have major implications on patient outcomes. Preliminary Image Evaluation (PIE) is a brief comment written by a radiographer describing an acute or traumatic pathology on a radiograph and ...
Jermayne Takapautolo, Michael Neep, Deborah Starkey   +2 more
doaj   +1 more source