Results 91 to 100 of about 390,338 (298)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2016 Thomas R Skinner,1 Ian A Scott,2,3 Jennifer H Martin3,4 1Department of Internal Medicine, Sunshine Coast Health Service District, Nambour Hospital, Nambour, QLD, Australia; 2Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital ...
Scott IA, Martin JH, Skinner TR
core
Sources of Diagnostic Errors in Lyme Disease
, 2019 Common sources of diagnostic errors in Lyme disease using the National Academy of Medicine schematic are identified.Author contact: lbjohnson@lymedisease ...
Lorraine Johnson (6290789)
core +1 more source
Medication safety in children [PDF]
, 2015 Background: The issue of medication safety has received considerable attention in the last few years. Especially drug related problems (DRP) are a major safety issue.
Glanzmann, C, Glanzmann, Corina
core +1 more source
Scandinavian Journal of Trauma, Resuscitation and Emergency MedicineBackground Diagnostic errors are a major care health concern but remain difficult to study because their identification often requires resource-intensive chart reviews.
Thimo Marcin +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Relating faults in diagnostic reasoning with diagnostic errors and patient harm.
, 2012 Purpose: The relationship between faults in diagnostic reasoning, diagnostic errors, and patient harm has hardly been studied. This study examined suboptimal cognitive acts (SCAs; i.e., faults in diagnostic reasoning), related them to the occurrence of ...
Wal, G. van der +5 more
core +1 more source
The Definition and Scope of Diagnostic Error in the US and How Diagnostic Error is Enabled [PDF]
The Journal of Applied Laboratory Medicine, 2018 Abstract Background The quality of healthcare in the US has been progressively addressed by 3 reports from the National Academy of Medicine, the latest of which, entitled “Improving Diagnosis in Health Care,” was issued in 2015 from a 21-member panel (the author of this report was a member).
openaire +2 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source