Results 61 to 70 of about 853,706 (301)

On the Early Diagnosis of Basal Cell Carcinoma (Case Description)

open access: yesКреативная хирургия и онкология, 2020
Introduction. Basal cell carcinoma represents one of the most common malignant skin tumours. This malignant skin neoplasm is characterised by slow growth and a weak tendency to metastasis, although the fatal outcome with an aggressive tumour growth is ...
M. A. Gomberg   +3 more
doaj   +1 more source

Diagnostics for insufficiencies of posterior calculations in Bayesian signal inference

open access: yes, 2013
We present an error-diagnostic validation method for posterior distributions in Bayesian signal inference, an advancement of a previous work. It transfers deviations from the correct posterior into characteristic deviations from a uniform distribution of
Dorn, Sebastian   +2 more
core   +1 more source

Background-oriented schlieren (BOS) for scramjet inlet-isolator investigation [PDF]

open access: yes, 2018
Background-oriented Schlieren (BOS) technique is a recently invented non-intrusive flow diagnostic method which has yet to be fully explored in its capabilities.
Idris, Azam Che   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Explanation-based learning for diagnosis [PDF]

open access: yes, 1992
Diagnostic expert systems constructed using traditional knowledge-engineering techniques identify malfunctioning components using rules that associate symptoms with diagnoses. Model-based diagnosis (MBD) systems use models of devices to find faults given
Fattah, Yousri El, O'Rorke, Paul
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

A Novel Method for the Fault Diagnosis of a Planetary Gearbox based on Residual Sidebands from Modulation Signal Bispectrum Analysis [PDF]

open access: yes, 2014
This paper presents a novel method for the fault diagnosis of planetary gearboxes based on an accurate estimation of residual sidebands using a modulation signal bispectrum (MSB).
Abdalla, Gaballa M.   +4 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

A mixed effect model for bivariate meta-analysis of diagnostic test accuracy studies using a copula representation of the random effects distribution [PDF]

open access: yes, 2015
Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives, because studies that
Arends   +51 more
core   +2 more sources

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