Results 171 to 180 of about 1,030,441 (312)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance (MGUS): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response. [PDF]

J Peripher Nerv Syst
van Veen R, Baars AE, van Doorn IN, Michael M, Bus SRM, Broers MC, van der Pol WL, Van Doorn PA, Drenthen J, Verhamme C, Vos JMI, van Schaik IN, Goedee HS, Wieske L, Jacobs BC, Eftimov F, ICOS Consortium.   +16 more
europepmc   +1 more source

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions. [PDF]

Invest Ophthalmol Vis Sci, 2022
Willems M, Wells CF, Coubes C, Pequignot M, Kuony A, Michon F.   +5 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Clinical and Diagnostic Features of Feline Epilepsy: Distribution of Seizure Types and Associated Factors. [PDF]

Animals (Basel)
Jankauskas M, Tamosauskaite J, Gradeckienė A, Čižinauskas S, Kvitka D, Riškevičienė V.   +5 more
europepmc   +1 more source

Determination of Diagnostic Features of Serum Thyroid Hormones and Thyroglobulin Ratios in Normothyroid Differentiated Thyroid Carcinoma Cases. [PDF]

Sisli Etfal Hastan Tip Bul, 2023
Aydogdu YF, Emreol U, Emre G, Buyukkasap C, Akin M.   +4 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis

, 2017
Sarah Chuzi,1 Fabio Tavora,2 Marcelo Cruz,3 Ricardo Costa,3 Young Kwang Chae,3 Benedito A Carneiro,3 Francis J Giles3 1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2Argos Laboratory, Messejana Heart and ...
Costa R, Chuzi S, Carneiro BA, Cruz M, Tavora F, Chae YK, Giles FJ   +6 more
core  

Conjunctival Squamous Cell Carcinoma: A Clinical Review of Diagnostic Features, Genetics, Current Management and an Update on Targeted and Immunotherapies. [PDF]

Cancers (Basel)
Mir M, Mudhar HS, Sagoo MS, Gichuhi S, Krishna Y.   +4 more
europepmc   +1 more source

Diagnostic features of type II fibrinoid leukodystrophy (Alexander disease) in a juvenile Beagle dog. [PDF]

J Vet Intern Med, 2023
Vandenberghe H, Baiker K, Nye G, Escauriaza L, Roberts E, Granger N, Reeve L.   +6 more
europepmc   +1 more source