Results 201 to 210 of about 6,677,261 (309)

Imaging diagnostic features of intracranial primary extranodal Rosai-Dorfman disease: Two case reports and literature review. [PDF]

Radiol Case Rep, 2023
Cao G, Xie S, Li M, Yang X, Zhu J, Zhang L.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies. [PDF]

Psychol Med
Hamilton CA, Donaghy PC, Taylor JP, Ciafone J, Durcan R, Firbank M, Greenfinch G, Allan L, O'Brien J, Thomas A.   +9 more
europepmc   +1 more source

ON-BOARD DIAGNOSTICS: FEATURES AND ALGORITHM OF DIAGNOSTICS

Universum:Technical sciences
Konstantin Chernov, Yuri Shevtsov
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Core diagnostic features of stiff person syndrome: insights from a case-control study. [PDF]

J Neurol
Roy S, Huang Y, Hu C, Fitzgerald KC, Wang Y, Newsome SD.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Microbial diagnostic features identified across populations possess potential antitumor properties in breast cancer. [PDF]

mSystems
Zhou M, Wang Q, Yang R, Zong Z, Huang B, Chen J, Bao X, Li S, Shen L, Dong J, Zhao X, Chen Y, Chen D.   +12 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Etiological spectrum and diagnostic features of lymphadenopathy in People Living with HIV in French Guiana: A 17-years multicenter retrospective case series. [PDF]

PLoS Negl Trop Dis
Bourne-Watrin M, Françoise U, Baron SA, Adenis AA, Pierre Louis D, Epelboin L, Nacher M, Djossou F, Drak Alsibai K, Couppié P.   +9 more
europepmc   +1 more source