Results 61 to 70 of about 3,884,045 (308)

Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma

, 2022
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality. Early detection of HCC is important since potentially curative therapies exist in the initial stages of HCC; no curative therapies exist for late-stage HCC.
Zheng, David X., Zheng, Qi-Huang, Grega, Shaun D.   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

High resolution, 3-dimensional Ferumoxytol-enhanced cardiovascular magnetic resonance venography in central venous occlusion

Journal of Cardiovascular Magnetic Resonance, 2019
Background Although cardiovascular magnetic resonance venography (CMRV) is generally regarded as the technique of choice for imaging the central veins, conventional CMRV is not ideal.
Puja Shahrouki, John M. Moriarty, Sarah N. Khan, Biraj Bista, Stephen T. Kee, Brian G. DeRubertis, Takegawa Yoshida, Kim-Lien Nguyen, J. Paul Finn   +8 more
doaj   +1 more source

A machine learning approach for differentiating malignant from benign enhancing foci on breast MRI

European Radiology Experimental, 2020
Background Differentiate malignant from benign enhancing foci on breast magnetic resonance imaging (MRI) through radiomic signature. Methods Forty-five enhancing foci in 45 patients were included in this retrospective study, with needle biopsy or imaging
Natascha C. D’Amico, Enzo Grossi, Giovanni Valbusa, Francesca Rigiroli, Bernardo Colombo, Massimo Buscema, Deborah Fazzini, Marco Ali, Ala Malasevschi, Gianpaolo Cornalba, Sergio Papa   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Postoperative MR Defecography following Failed STARR Procedure for Obstructive Defecation Syndrome: A Three-Centre Experience

Gastroenterology Research and Practice, 2017
Aim. To describe the abnormalities at MR imaging and related complaints in patients with poor outcome after STARR procedure. Materials and Methods. The medical records of 21 symptomatic patients from centre 1, 31 patients from centre 2, and 63 patients ...
Vittorio Piloni, Marco Possanzini, Mattia Bergamasco, Gianluca Santi   +3 more
doaj   +1 more source

Improved Sweat Artifact Tolerance of Screen-Printed EEG Electrodes by Material Selection-Comparison of Electrochemical Properties in Artificial Sweat

IEEE Access, 2019
The accurate diagnosis of sleep disorders requires an electroencephalography (EEG) recording. However, in-home EEG-based sleep monitoring has been hindered by the present cumbersome electrode systems which are impractical for patient self-application. To
Laura Kalevo, Tomi Miettinen, Akseli Leino, Samu Kainulainen, Katja Myllymaa, Juha Toyras, Timo Leppanen, Sami Myllymaa   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bladder perforation in the elderly: unraveling the diagnostic challenges with magnetic resonance imaging

, 2023
Bladder perforation, a significant urological emergency, presents a diagnostic challenge due to its diverse etiologies and varying clinical manifestations.
Lopes, Mari Angela, Arez, Luísa, Simões, Inês G., Valente, Dilia, Silva, Frederico   +4 more
core   +1 more source

Multimodale Bildgebung in der pädiatrischen Onkologie [PDF]

, 2013
The evaluation of multimodal imaging in paediatric oncology is the main theme of this thesis. Both published studies evaluate 18F-fluorodesoxyglucose positron emission tomography (18FFDG-PET) combined with an additional imaging modality in paediatric ...
Melzer, Henriette Ingrid
core   +1 more source