Results 81 to 90 of about 1,530,885 (295)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Hereditary leptomeningeal transthyretin amyloidosis with heterozygous TTR mutation: a case report and literature review

Orphanet Journal of Rare Diseases
Objective This study aimed to characterize the clinical and neuroimaging features of hereditary leptomeningeal transthyretin amyloidosis (hATTR-LA), a dominant inheritance disorder caused by a heterozygous TTR gene mutation.
Hong-Tao Chen, You-Jun Tian, Jue Zhang, Bing-Rong Xiao, Ke Yang, Ya-Li Zhang   +5 more
doaj   +1 more source

Three Dimensional Electrical Impedance Tomography [PDF]

, 1996
The electrical resistivity of mammalian tissues varies widely and is correlated with physiological function. Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a non-invasive means of imaging the internal ...
A Albert, AM Dijkstra, B. H. Brown, BH Brown, BH Brown, CJ Kotre, D. C. Barber, DA Witsoe, DB Geselowitz, DC Barber, DC Barber, DC Barber, DC Barber, DC Barber, DS Holder, ET McAdams, FA Duck, GH Golub, J Goble, JP Morucci, KS Rabbani, LA Geddes, P. Metherall, PC Hansen, R Pethig, R. H. Smallwood, RD Stoy, SG Dawids   +27 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Discrepancies between Coronary Artery Calcium Score and Coronary Artery Disease Severity in Computed Tomography Angiography Studies

Diagnostics
The aim of this paper is to demonstrate the difference in usefulness of the coronary artery calcium score (CACS) and the full assessment of the severity of coronary artery disease in coronary computed tomography angiography (CCTA) studies. The difference
Paweł Gać, Arkadiusz Jaworski, Agnieszka Parfianowicz, Jakub Karwacki, Andrzej Wysocki, Rafał Poręba   +5 more
doaj   +1 more source

Cone beam CT of the musculoskeletal system : clinical applications [PDF]

, 2018
Objectives: The aim of this pictorial review is to illustrate the use of CBCT in a broad spectrum of musculoskeletal disorders and to compare its diagnostic merit with other imaging modalities, such as conventional radiography (CR), Multidetector ...
Desimpel, Julie, Posadzy, Magdalena, Vanhoenacker, Filip   +2 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

FlexICL: A Flexible Visual In-Context Learning Framework for Elbow and Wrist Ultrasound Segmentation

IEEE Access
Elbow and wrist fractures are the most common fractures in pediatric populations. Automatic segmentation of musculoskeletal structures in ultrasound (US) can improve diagnostic accuracy and treatment planning.
Yuyue Zhou, Jessica Knight, Shrimanti Ghosh, Banafshe Felfeliyan, Jacob L. Jaremko, Abhilash Rakkunedeth Hareendranathan   +5 more
doaj   +1 more source

The U.S. Health System in Perspective: A Comparison of Twelve Industrialized Nations [PDF]

, 2011
Compares the U.S. health system to those of twelve OECD countries based on measures of spending; physician supply and visits; utilization, supply, and prices of drugs and diagnostic imaging; and performance.
David A. Squires
core