Results 121 to 130 of about 1,679,146 (250)

Pitfalls in the diagnosis of melanocytic tumours: is immunohistochemistry helpful?

Polish Journal of Pathology
The diagnosis and differential diagnosis of benign, intermediate and malignant melanocytic neoplasms remain a recurring and clinically important challenge in dermatopathology.
Thomas Mentzel
doaj   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Endoscopic ultrasound-guided fine needle aspiration biopsy — diagnostic principles and workup

Nowotwory
Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) is a well-recognized diagnostic tool of highsensitivity (60–95%) and specificity (85–100%) for diagnosing solid, cystic, and solid-cystic lesions in the gastrointestinaltract ...
Małgorzata Lenarcik, Magdalena Misiak-Gałązka, Andrzej Mróz   +2 more
doaj   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

p16 immunohistochemistry for melanocytic neoplasia: A meta-analysis of diagnostic accuracy studies

The gold standard for diagnosis of melanoma is histopathology. However, diagnosis by histopathology can be challenging. Interobserver discordance on benign versus malignant classification of melanocytic lesions by histopathology is not infrequent, even ...
Shruti Chinchanikar, Garth Fraga
core   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. [PDF]

Adv Anat Pathol, 2018
Schaefer IM, Hornick JL.
europepmc   +1 more source

Immunohistochemistry in the Postmortem Diagnosis of Sepsis: A Systematic Review

, 2019
It is not uncommon for the forensic pathologist to question whether a deceased person had experienced sepsis that could have either been the cause of or contributed to the person's death.
Francesco Ventura, Barranco, Rosario, Ventura, Francesco, Rosario Barranco   +3 more
core   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Combined immunohistochemistry and FISH testing for diagnosing metaplastic thymoma: a case report of misdiagnosis as pulmonary mucinous epidermoid carcinoma

Frontiers in Surgery
Simple summaryDifferentiating metaplastic thymoma from pulmonary mucoepidermoid carcinoma through immunohistochemistry and FISH testing provides diagnostic evidence for clinical practice.
Jiaxin Liu, Xiang Yu, Wenquan Li, Chunhui Shen, Zhenhui Wang, Jiyong Wang   +5 more
doaj   +1 more source