Results 91 to 100 of about 3,425,877 (325)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Assessment of Quanti FERON-TB Gold (In-Tube) Test in Tuberculosis Diagnosis

مجله اپیدمیولوژی ایران, 2010
Background & Objective: Because of uncertainty in interpretation of some tests for diagnosing TB, decision making for the tuberculosis treatment is based on multiple diagnostic tests.
H Lashkardoost, B Zeighami, M Mahmoudi, J Hassanzadeh, A Hamedi, HR Tabatabaee, F Sameemanesh, SM Kashfi   +7 more
doaj  

Free Kappa light chain in a sample of Egyptian multiple sclerosis patients (a pilot study)

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Multiple sclerosis is a chronic autoimmune-mediated demyelinating disease of the central nervous system that is usually associated with varying degrees of progressive disability. Free Kappa light chain (FKLC) has attracted growing attention as
Abeer Elsayed Aly Shehab, Salwa Ibrahim Bakr, Rasha Mamdouh Saleh, Dina Aly Ragab, Maryam Gamal Salem, Mohamed Aly Abdel Hafeez   +5 more
doaj   +1 more source

Near-infrared spectroscopy of stellar populations in nearby spiral galaxies

, 2012
We present high spatial resolution, medium spectral resolution near-infrared (NIR) H- and K-band long-slit spectroscopy for a sample of 29 nearby (z < 0.01) inactive spiral galaxies, to study the composition of their NIR stellar populations.
Ali, Alonso-Herrero, Bendo, Bernardi, Bernardi, Bettoni, Beuing, Burston, Carollo, Cavallo, Cesetti, Coziol, Dalle Ore, Dannerbauer, Davies, de Souza, Denisenkov, Denissenkov, Dressler, Engelbracht, Faber, Fremaux, Frogel, Förster Schreiber, Goldader, Golev, Hamuy, Hyvönen, Héraudeau, Idiart, Ivanov, Ivanov, Ivanov, J. K. Kotilainen, J. Reunanen, Jablonka, Kleinmann, Langer, Lançon, Larkin, Leitherer, Mannucci, Mannucci, Maraston, Mayya, McElroy, Mehlert, Merrill, Mobasher, Moorwood, Oliva, Origlia, Paturel, Ramirez, Reunanen, Reunanen, Reunanen, Riffel, Riffel, Schechter, Silva, T. Hyvönen, Trager, V. D. Ivanov, Vanzi, Vega Beltrán, Vázquez, Wallace, Wallace, Wallace, Wegner, Whitmore, Worthey, Worthey, Worthey, Worthey   +75 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Monitoring Fetal Heart Rate during Pregnancy: Contributions from Advanced Signal Processing and Wearable Technology [PDF]

, 2014
Monitoring procedures are the basis to evaluate the clinical state of patients and to assess changes in their conditions, thus providing necessary interventions in time.
Andrea Fanelli, Giovanni Magenes, Maria G. Signorini   +2 more
core   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Can emerging African Stock Markets improve their informational efficiency by formally harmonising and integrating their operations? [PDF]

Despite experiencing rapid growth in their number and size, African stock markets remain highly segmented, small, illiquid and technologically bankrupt, severely affecting their informational efficiency.
Danbolt, Jo, Dewotor, Frank, Ntim, Collins G, Opong, Kwaku K   +3 more
core   +1 more source

Social fragmentation, deprivation and urbanicity: relation to first-admission rates for psychoses [PDF]

, 2005
<i>Declaration</i> <i>of</i> <i>interest</i>: None. <i>Background</i>: Social disorganisation, fragmentation and isolation have long been posited as influencing the rate of psychoses at area level ...
Carr-Hill, Carstairs, Faris, Harley, Harper Gilmour, Jacqueline Atkinson, Jennifer Bishop, Judith Allardyce, Kendrick, McLoone, Midwinter, R. G. McCreadie, Tracey Rapson   +12 more
core   +1 more source