Results 51 to 60 of about 198,633 (304)

Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study

open access: yesMetabolites, 2023
During the initial diagnosis of urgent medical conditions, which include acute infectious diseases, it is important to assess the severity of the patient’s clinical state as quickly as possible.
Nikolay V. Goncharov   +9 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Diagnostic indices of E6/E7 mRNA analyses for detecting invasive cervical cancer.

open access: yes, 2018
Diagnostic indices of E6/E7 mRNA analyses for detecting invasive cervical cancer.
Nobutaka Tasaka (4333810)   +15 more
core   +1 more source

Novel Indices to Improve the Diagnostic Ability of Nocturnal Oximetry in Children with OSAS

open access: yes, 2023
Nocturnal pulse oximetry (NOx) is an alternative diagnostic test for obstructive sleep apnea syndrome (OSAS) in childhood yet with variable diagnostic performance.
Magdalene Tsiakou   +10 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Predictive and Diagnostic Values of Systemic Inflammatory Indices in Bronchopulmonary Dysplasia

open access: yesChildren, 2023
Background: Bronchopulmonary dysplasia (BPD) is the most common respiratory complication in preterm infants, and there is a lag in the diagnosis of BPD.
Linxia Cao   +6 more
doaj   +1 more source

Colonoscopy: Evaluating Indications and Diagnostic Yield

open access: yesAnnals of Saudi Medicine, 2001
Colonoscopic procedure is an accepted modality for the evaluation of colonic disease. Open-access versus restricted-access colonoscopy has been argued over in the recent literature. The aim of this retrospective analysis is to identify the yield of the major indications for the procedure, and the pattern of colon pathology in our community.We ...
M A, Al-Shamali   +5 more
openaire   +2 more sources

Diagnostic value of systemic inflammatory indices in ectopic pregnancy

open access: yesMedicine Science
This study aims to evaluate the diagnostic and prognostic utility of systemic inflammatory indices in patients with ectopic pregnancy, and to assess whether they may serve as readily obtainable indicators for early diagnosis and informed clinical ...
Meryem Bekmezci, Huseyin Erdal
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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