Results 91 to 100 of about 1,862,073 (282)

Formalizing cognitive biases in medical diagnostic reasoning

, 2022
Battefeld D, Kopp S. Formalizing cognitive biases in medical diagnostic reasoning. In: Proceedings of the 8th Workshop on Formal and Cognitive Reasoning (FCR).
Kopp, Stefan ; https://orcid.org/, Battefeld, Dominik ; https://orcid.org/   +1 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Diagnostic reasoning: a single entity diagnosis is often inadequate [PDF]

, 2022
Whitehouse, William P
core   +1 more source

Diagnostic reasoning in osteopathy – a qualitative study [PDF]

, 2014
The clinical reasoning processes which result in the formation of a diagnosis, are fundamental for safe, effective and efficient clinical practice and are central to professional autonomy and accountability.
Petty, Nicola, Moore, A, Moore, A., Thomson, Oliver P., Petty, N   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Diagnostic Performance and Workup Efficiency of Large Language Models in Secondary Hypertension: A Blinded Comparative Study

Diagnostics
Background/Objectives: Secondary hypertension (SH) requires complex diagnostic reasoning and guideline-based management, posing substantial challenges for artificial intelligence–driven clinical decision-support systems. This study aimed to comparatively
Asena Gökçay Canpolat, Özge Baş Aksu, Rıfat Emral, Uğur Canpolat   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

[Diagnostic reasoning in patients with multimorbidity].

Nederlands tijdschrift voor geneeskunde, 2021
Contains fulltext : 237593.pdf (Publisher’s version ) (Open Access)
Olde Rikkert, M.G.M., Lieverse, J.D., Uleman, J.F., Beeres, M.P.J., Stolper, C.F.   +4 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Influence of perceived difficulty of cases on student osteopaths’ diagnostic reasoning: a cross sectional study

Chiropractic & Manual Therapies, 2017
Background Diagnostic reasoning refers to the cognitive processes by which clinicians formulate diagnoses. Despite the implications for patient safety and professional identity, research on diagnostic reasoning in osteopathy remains largely theoretical ...
Aurelien L. Noyer, Jorge E. Esteves, Oliver P. Thomson   +2 more
doaj   +1 more source