Results 81 to 90 of about 69,936 (251)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Investigating The Problem of Misdiagnosis in Model–Based Fault Diagnosis

International Journal of Applied Mathematics and Computer Science
This paper deals with one partly unconscious property of the model-based diagnosis. It discusses occasional contradictions between diagnoses that are logically correct but, in fact, are not consistent with the physical state of the system being diagnosed.
Kóscielny Jan Maciej, Bartyś Michał
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reinforcement of core foundational science concepts during clinical rotations: a strategy to enhance medical student learning and diagnostic reasoning

Advances in Physiology Education
Cognitive science principles can facilitate integrating and retaining basic science concepts during the clinical years of undergraduate medical education.
Bindu Menon, Meghana Reddy Ranabothu, Krissy Elizabeth Tarter, Tyrone Deonte Oneal Layson, Deepa Mukundan, Jeremy J. Laukka   +5 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Ontology-Based Root Cause Fault Diagnostic Reasoning for Airborne Systems

Aerospace
Root cause fault diagnostic reasoning is critical for ensuring the safety and reliability of airborne systems, where timely and accurate fault isolation can significantly reduce downtime and maintenance costs.
Zhiyu She, Cunbao Ma, Jin Zhao, Jing Qu
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Overcoming Anchoring Bias in Tuberculous Lymphadenitis with Non-Specific Ultrasound: A Case of Diagnostic Excellence in Primary Care

Journal of Hospital General Medicine
Tuberculous lymphadenitis is the most common form of extrapulmonary tuberculosis; however, diagnostic delays can occur when classic ultrasound features, such as central necrosis or matting, are absent.
Takayuki Yamada, Hideharu Nakamura
doaj   +1 more source

A Universal Model of Diagnostic Reasoning

Academic Medicine, 2009
Clinical judgment is a critical aspect of physician performance in medicine. It is essential in the formulation of a diagnosis and key to the effective and safe management of patients. Yet, the overall diagnostic error rate remains unacceptably high.
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source