Results 81 to 90 of about 284,617 (309)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Using script theory to cultivate illness script formation and clinical reasoning in health professions education

Canadian Medical Education Journal, 2015
Background: Script theory proposes an explanation for how information is stored in and retrieved from the human mind to influence individuals’ interpretation of events in the world.
Stuart Lubarsky, Valérie Dory, Marie-Claude Audétat, Eugène Custers, Bernard Charlin   +4 more
doaj  

Information with diagnostic technical object used to create experts’ knowledge base [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2017
The article presents the problem of determining diagnostic information for the purpose of testing a complex technical object. To this end, the essence of the development of the functional-diagnostic model was presented and described on the example of the
Radosław Duer, Stanisław Duer
doaj   +1 more source

The VEX-93 environment as a hybrid tool for developing knowledge systems with different problem solving techniques [PDF]

, 1997
The paper describes VEX-93 as a hybrid environment for developing knowledge-based and problem solver systems. It integrates methods and techniques from artificial intelligence, image and signal processing and data analysis, which can be mixed.
García Martínez, Ada, García, Yazna, Hernández, Dania, Hita Rensoli, Ramon María de, Paredes, Raul, Peón Valdés, Katia, Rodríguez, Alfredo, Valdés Ramos, Julio José   +7 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

How Does Explanatory Virtue Determine Probability Estimation?—Empirical Discussion on Effect of Instruction

Frontiers in Psychology, 2020
It is important to reveal how humans evaluate an explanation of the recent development of explainable artificial intelligence. So, what makes people feel that one explanation is more likely than another?
Asaya Shimojo, Kazuhisa Miwa, Hitoshi Terai   +2 more
doaj   +1 more source

Education debate: clinical diagnostic reasoning [PDF]

Internal Medicine Journal, 2011
AbstractWhilst it is clear that experienced clinicians adopt a rational approach of diagnosis, the logic of their clinical reasoning has been difficult to define. I outline here an approach based on the four categories of a complete diagnosis: Anatomical diagnosis (system involved); Pathological diagnosis (nature of the condition); Physiological ...
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Reinforcement of core foundational science concepts during clinical rotations: a strategy to enhance medical student learning and diagnostic reasoning

Advances in Physiology Education
Cognitive science principles can facilitate integrating and retaining basic science concepts during the clinical years of undergraduate medical education.
Bindu Menon, Meghana Reddy Ranabothu, Krissy Elizabeth Tarter, Tyrone Deonte Oneal Layson, Deepa Mukundan, Jeremy J. Laukka   +5 more
doaj   +1 more source