Results 141 to 150 of about 9,461,475 (306)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Skin biopsy in adult-onset Still's disease: A specific, rapid, and widely available diagnostic test. [PDF]

J Hum Immun
Chong DHY, Spaner C, Elsharawi I, Trinder M, Al Bitar H, Goubran M, Perrotta A, Horner R, Chen D, Corpuz J, Huang K, Taylor T, Lano IM, Purdy K, Dutz JP, Pasternak S, Crawford RI, Chen LYC.   +17 more
europepmc   +1 more source

GPSPS. German Personal Sense of Power Scale

Die deutsche Adaptation GPSPS misst mit je 6 Items die subjektive Macht als Trait- oder State-Komponente sowie in verschiedenen Beziehungstypen. Reliabilität: Die interne Konsistenz lag zwischen α/ω = .78 und α/ω = .89.
Körner, R.
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Comparison of Different Methods for the Meta-Analysis of Diagnostic Test Accuracy Studies-A Simulation Study. [PDF]

Biom J
Stoye FV, Raths O, Hapfelmeier A, Fomenko A, Kuss O, Hoyer A.   +5 more
europepmc   +1 more source

Screening to Assess Psychosocial Follow-Up Needs in Pediatric Oncology (Self- and Parent-Report)

Der NPO-11 dient als Screening zur Einschätzung des psychosozialen Nachsorgebedarfs in der pädiatrischen Onkologie im Selbst- und Elternbericht. Anhand von Expertenangaben wurden jeweils 11 Items für die Nachsorgebereiche Progredienzangst, Traurigkeit ...
Kamm-Thonwart, R., Hoffmann, R., Kulisch, L., Schepper, F., Jäschke, Y., Martini, J., Herrmann, J., Herzog, K., Graf Einsiedel, H.   +8 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

CASQ. Coping Across Situations Questionnaire

Der CASQ erfasst das individuelle Bewältigungsverhalten von Jugendlichen in belastenden Situationen. 20 Bewältigungsstrategien in acht altersspezifischen Problembereichen werden den drei Subskalen "Aktive Bewältigung", "Internale Bewältigung" und ...
Seiffge-Krenke, I.
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Accuracy and Usability of a New Rapid Diagnostic Test for the Diagnosis of Dengue in Vientiane, Laos. [PDF]

Open Forum Infect Dis
Phimolsannousith V, Sibounheuang B, Chanthongthip A, Vongsouvath M, Mayxay M, Mukaka M, Luangraj M, Newton PN, Ashley EA, Hopkins H, Dubot-Pérès A.   +10 more
europepmc   +1 more source