Results 121 to 130 of about 1,288,068 (341)

Preoperative laboratory evaluation of patients aged over 40 years undergoing elective non-cardiac surgery

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Although it is generally agreed that a medical history and physical examination should be obtained as part of preoperative evaluation, there is still substantial controversy about the additional benefits of preoperative screening ...
Fábio Yoshito Ajimura, Alex Silva Santos Freire Maia, Adriana Hachiya, Alexandra Sayuri Watanabe, Maria do Patrocínio Tenório Nunes, Mílton de Arruda Martins, Fábio Santana Machado   +6 more
doaj   +1 more source

Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea [PDF]

, 2010
Accurate diagnosis of Plasmodium infections is essential for malaria morbidity and mortality reduction in tropical areas. Despite great advantages of light microscopy (LM) for malaria diagnosis, its limited sensitivity is a critical shortfall for ...
Barnadas, Céline, Siba Peter, Betuela Inoni, Mueller Ivo, Zimmerman, Peter A., Rosanas-Urgell, Anna, Felger Ingrid, Felger, Ingrid, Rosanas-Urgell Anna, Dania Mueller, Mueller, Dania, Céline Barnadas, Ingrid Felger, Del Portillo, HA, Iga, Jonah, Felger, I, Hernando A del Portillo, Mueller, Ivo, Mueller Dania, Mueller, D, Anna Rosanas-Urgell, Siba, P, del Portillo, Hernando A., del Portillo Hernando A, Ivo Mueller, Iga Jonah, Peter Siba, Zimmerman, PA, Siba, Peter, Barnadas, C, Betuela, Inoni, Mueller, I, Barnadas Céline, Inoni Betuela, Jonah Iga, Betuela, I, Zimmerman Peter A, Peter A Zimmerman, Iga, J, Rosanas-Urgell, A   +39 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Moustiquaires imprégnées d'insecticides longue durée et tests diagnostiques rapides du paludisme : implication dans le contrôle du paludisme au centre de la Côte d'Ivoire [PDF]

, 2013
Malaria is a vector-borne disease that primarily affects rural dwellers in the tropics and subtropics. In areas of high transmission, the highest mortality and morbidity rates are found in rural settings with seasonal variations that might be governed by
Ouattara, Allassane Foungoye
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study

Malaria Journal, 2011
BackgroundPresumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic tests (m RDTs) on prescription of anti-malarials in urban Tanzania ...
V. D’Acremont, J. Kahama-Maro, N. Swai, D. Mtasiwa, B. Genton, C. Lengeler   +5 more
semanticscholar   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Rapid diagnostic tests as a source of DNA for Plasmodium species-specific real-time PCR

Malaria Journal, 2011
BackgroundThis study describes the use of malaria rapid diagnostic tests (RDTs) as a source of DNA for Plasmodium species-specific real-time PCR.MethodsFirst, the best method to recover DNA from RDTs was investigated and then the applicability of this ...
L. Cnops, M. Boderie, P. Gillet, M. van Esbroeck, J. Jacobs   +4 more
semanticscholar   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source