Results 71 to 80 of about 605,483 (283)

The diagnostic value of anti-neutrophil cytoplasmic antibody testing in a routine clinical setting [PDF]

QJM, 2001
Anti-neutrophil cytoplasmic antibody (ANCA) tests are a routine clinical assay in most UK hospitals. We examined the role of routine ANCA testing in achieving a diagnosis of systemic vasculitis in a routine clinical setting. From April 1996 to March 2000, 2734 samples from five hospital departments were tested for ANCA by indirect immunofluorescence ...
McLaren, J, Stimson, R, McRorie, E, Coia, J, Luqmani, R   +4 more
openaire   +4 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Overnight Dexamethasone Suppression Test in the Diagnosis of Cushing's Disease

Acta Medica Iranica, 2010
Realizing the cause of Cushing's Syndrome (CS) is one of the most challenging processes in clinical endocrinology. The long high dose dexamethasone suppression test (standard test) is costly and need an extended inpatient stay.
Fatemeh Esfahanian, Rozana Kazemi
doaj  

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Factors influencing the use of bed nets in Mbarara municipality of Uganda. [PDF]

, 2001
In order to identify independent predictors for bed net use, respondents from 643 households selected randomly from 21 clusters were interviewed in Mbarara municipality, Uganda.
Nuwaha, F
core   +1 more source

From laboratory bench to benchmark: technology transfer in laboratory medicine [PDF]

, 2020
Background: Life Sciences research, enhancing the occurrence of innovation, is able to impact clinical decision-making, both at diagnosis and therapy. Indeed, starting from the knowledge of specific needs and of technical-scientific demands, researchers ...
Cariati, Federica, D’Argenio, Valeria, Izquierdo, Raul, Tomaiuolo, Rossella   +3 more
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The clinical features of the piriformis syndrome: a systematic review [PDF]

, 2010
Piriformis syndrome, sciatica caused by compression of the sciatic nerve by the piriformis muscle, has been described for over 70 years; yet, it remains controversial. The literature consists mainly of case series and narrative reviews. The objectives of
A Chantraine, A Hulbert, A Ku, A Miller, AG Filler, AH Freiberg, AH Freiberg, AJ Sutton, AM Lewis, B Gandhavadi, B Kumar, BSE Rich, C Steiner, CC Stegbauer, CE Dionne, CW Chang, CW Slipman, D Pokorny, D West, DA Jabs, DL Kent, DR Robinson, E Ernst, E Ernst, E Ernst, E Ernst, EC Papadopoulos, EC Yuen, EM Raney, ER Benson, EW Retzlaff, EY Lee, F Cramp, Fujian Song, G Waddell, GM Wyant, H Nakamura, HF Guyomarc’h, HI Pecina, HT Benzon, HW Park, I Colmegna, I Kosukegawa, IM Merlo, J Dalmau-Carola, J Karppinen, J Kouvalchouk, J Soga, J Young, JA Adams, JA Brown, JB Pace, JD Stewart, JJ Jankiewicz, JK Silver, JP Vandenbroucke, JS Kirschner, JWT Byrd, K Hopayian, K Indrekvam, K Konstantinou, Kevork Hopayian, KJ Stevens, KW Chong, L Jroundi, LF Solheim, LM Fishman, LM Fishman, LM Fishman, M Hanania, M Jenicek, M Pecina, M Tulder van, MC Vallejo, ME Julsrud, MR Foster, MR Foster, MW Cook, N Mayrand, NA Broadhurst, OA El Rubaidi, P Kobbe, P Limongelli, P Rossi, PM Barton, PM Bossuyt, R Dhote, RA Beatty, RD Karl Jr, Ricardo Riera, RJ Spinner, RL Tiel, RL Tiel, RP Beauchesne, RP Hallin, RR Richardson, S Bustamante, S Ozaki, S Turtas, SC Sayson, Sidha Sambandan, SJ Yoon, SM Papadopoulos, SM Papadopoulos, SS Hughes, T Banerjee, T Rodrigue, TN Bernard, TS Carey, V Rucco, VM Synek, VM Synek, WJ Mixter, WP Vandertop, WS Chen, WS Chen, WS Chen, Z Durrani   +117 more
core   +2 more sources