Results 111 to 120 of about 3,348,290 (301)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Frontiers in MedicineIntroductionMediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy (EBUS-TDB), which uses a laser as a tunneling and incision tool, may yield more ...
Wenyu Zhan +5 more
doaj +1 more source
Diagnostic Accuracy of EUS versus MRCP for Extrahepatic Biliary Tract Disorders: A Prospective Observational Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Accurate diagnosis of Extrahepatic Biliary Tract Disorders (EHBTDs) is essential for guiding appropriate management. Magnetic Resonance Cholangiopancreatography (MRCP) is a widely used non-invasive modality but may miss small calculi or ...
Divij Agarwal, Varun S Shetty, Iqbal Ali
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
CT Preoperative Imaging of Esophageal Cancer: Is Inclusion of Abdomen Necessary?
The Annals of African Surgery, 2020 Background: Esophageal carcinoma is the third commonest tumor in Kenya with one of the highest mortality rates. Locally, the 2019 Kenya National Cancer Treatment Protocols recommend CT chest and abdomen as the basic imaging tool.
Martin Ian Kamanda
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Gut and Liver, 2010 Background/Aims: Video capsule endoscopy (CE) can provide a negative result despite the presence of clinically significant small-bowel lesions. We therefore performed a prospective study to elucidate whether repeated back-to-back CE increases the ...
doaj +1 more source
Parsimoneous Modeling of Yield Curves for U.S. Treasury Bills [PDF]
A new model is proposed for representinq the term to maturity structure of interest rates at a point in time.The model produces humped, monotonic and S-shaped yield curves using four parameters.
Andrew F. Siegel, Charles R. Nelson
core
, 2019 Diagnostic yield of algorithms including microscopy or Xpert with and without LAM and additional yield of LAM in patients with laboratory-confirmed TB.
Kuzani Mbendera (6650648) +10 more
core +1 more source