Results 161 to 170 of about 3,348,290 (301)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Diagnostic yield and outcomes of hand surgery referrals to rheumatology. [PDF]

Bull Hosp Jt Dis (2013)
Seltzer R, Kavarana S, Jamal N, Locascio L, Mead R, Byram K, Maslow J.   +6 more
europepmc   +1 more source

The effect of non-medical factors on variations in the performance of colonoscopy among different health care settings [PDF]

Background: Previous studies in the literature have shown significant variations in colonoscopy performance, even when medical factors are taken into account. This study aimed to examine the role of non-medical factors (i.e.
Pascal Juillerat, Bernard Burnand, Alberto Holly, Vincent Wietlisbach, John-Paul Vader, Florian Froehlich, Karine Lamiraud, Jean-Jacques Gonvers   +7 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Diagnostic Yield of Internal Medicine Referrals to Rheumatology: A Retrospective Single-Center Study. [PDF]

Medicina (Kaunas)
Dağlı PA, Armağan B, Konak HE, Bilen Ayhan S, Özdemir ZÖ, Özel EM, Büyükaksoy M, Sözen ES, Atalar E, Koçak Ulucaköy R, Kayacan Erdoğan E, Güven SC, Doğan İ, Orhan K, Maraş Y, Küçükşahin O, Omma A, Erten Ş, Babaoğlu H.   +18 more
europepmc   +1 more source

Reliability, diagnostic value, and diagnostic yield of ultrasound-guided percutaneous core needle biopsy for peritoneal lesions

IntroductionPeritoneal lesions cannot be definitively distinguished based on clinical and imaging characteristics alone. This study aimed to evaluate the reliability, diagnostic value, and diagnostic yield of ultrasound-guided percutaneous core needle ...
Comut, Erdem, Aslan, Halil Serdar, Utebey, Ayşe Ruksan, Arslan, Muhammet, Kılıç, Derya, Vurgun, Sercan, Degirmencioğlu, Serkan   +6 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Diagnostic Yield of Hospitalization for Emergency Department Patients With Syncope and Presyncope. [PDF]

Acad Emerg Med
Baugh CW, Winskill C, Suh EH, Sacco DL, DeAngelis J, Nishijima DK, Schimmel J, Storrow AB, Wood N, Weiss RE, Probst MA.   +10 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source