Results 181 to 190 of about 3,348,290 (301)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Deep tissue sequencing improves genetic diagnostic yield in focal cortical dysplasia. [PDF]

Prog Neuropsychopharmacol Biol Psychiatry
Galea B, Reid J, Gooley S, Witkowski T, Lane T, Macdonald S, Green TE, Ye Z, Adikari T, Bulluss K, Mullen SA, Bennett CA, Forster B, Bradshaw G, Lin W, De Silva W, Ramirez RB, Khoshkhoo S, Gupta S, Krivanek M, Kothur K, Gill D, Pope K, Gillies G, Coleman M, Lee WS, Stephenson SM, Maixner W, Harvey AS, Macdonald-Laurs E, Howell KB, D'Arcy C, Lockhart PJ, Leventer RJ, Kalnins RM, Clark J, Bennett MF, Bahlo M, Scheffer IE, Perucca P, Berkovic SF, Hildebrand MS.   +41 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Diagnostic Yield of Expanded Multigene Testing in Hereditary Polyposis Syndromes: Functional Characterization of Clinically Relevant Variants. [PDF]

Cancer Genomics Proteomics
Martín EM, Arranz-Ledo M, Aras EL, Hernández AO, Alonso RF, Sanz LH, Martín NM, Sanz MI, Domínguez MD.   +8 more
europepmc   +1 more source

Low Diagnostic Yield of Elective Coronary Angiography [PDF]

New England Journal of Medicine, 2010
Antonio, Abbate, George, Vetrovec, Filippo, Crea   +2 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Stratified Use of Genetic Testing in Liver Disease Improves Diagnostic Yield and Clinical Impact. [PDF]

Int J Mol Sci
Faini AC, Pinon M, Brach Del Prever GM, Romeo CM, Luca M, Mioli F, Saglia C, Scolari C, Carradori T, Arruga F, Chiadò C, Morgando A, Martini S, Romagnoli R, Bugianesi E, Carli D, Vaisitti T, Deaglio S, Calvo PL.   +18 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Genetic Spectrum of Cholestasis in Tunisia and Diagnostic Yield of Next-Generation Sequencing: Case Series of 70 Patients. [PDF]

Clin Genet
Abdmouleh A, Jilani H, Rejeb I, Hizem S, Pottier N, Larrue R, Arondal W, Hanquet L, Benrabeh R, Bouyahia O, Mazigh S, Elaribi Y, Benjemaa L.   +12 more
europepmc   +1 more source