Results 101 to 110 of about 76,976 (307)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Revisiting Gassmann-type relationships within Biot poroelastic theory [PDF]

Solid Earth
Gassmann's equations have long served as a cornerstone of geophysics and rock physics, widely regarded as exact within their domain of applicability. However, recent studies have questioned their validity, arguing that Gassmann's derivation involves a ...
Y. Alkhimenkov, Y. Y. Podladchikov
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The rank of the diagonal and submetrizability [PDF]

, 2006
summary:Several topological properties lying between the submetrizability and the $G_\delta $-diagonal property are studied. We are mostly interested in their relationship to each other and to the submetrizability.
R. Z. Buzyakova, A. V. Arhangel’skii, Buzyakova, R. Z., Arhangel'skii, A. V.   +3 more
core  

Vanishing results in Chow groups for the modified diagonal cycles

, 2022
We prove a sufficient condition for the vanishing of the modified diagonal cycle in the Chow group (with $\mathbb{Q}$-coefficients) of the triple product of a curve over $\mathbb{C}$.
Qiu, Congling, Zhang, Wei
core   +1 more source

A condition for diagonalization modulo arbitrary norm ideals

Journal of Functional Analysis, 2008
Let \(\mathcal C\) be a norm ideal and \((A_1, \dots,A_n)\) be a commuting tuple of self-adjoint operators on a separable Hilbert space \(\mathcal H\). Continuing previous investigations from a series of articles in the same journal, the author considers the problem of determining whether or not \((A_1,\dots,A_n)\) can be simultaneously diagonalized ...
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Extremal properties of balanced tri-diagonal matrices

, 1969
If A A is a square matrix with distinct eigenvalues and D D a nonsingular matrix, then the angles between row- and column-eigenvectors of D − 1
Peter A. Businger
core   +1 more source

Axial compression and shear behaviour of hollow brick masonry wall panels with plaster-mesh bed-joint reinforcement under summer and winter construction conditions

Engineering Science and Technology, an International Journal
Masonry construction in cold regions is highly vulnerable to insufficient early-age curing, which can suppress mortar hydration and weaken the brick–mortar interface, ultimately reducing structural reliability.
Muhammet Şahin, Dilek Okuyucu, Burak Şahin, Burak Gedik   +3 more
doaj   +1 more source