Results 101 to 110 of about 2,699,147 (306)

Revisiting Gassmann-type relationships within Biot poroelastic theory [PDF]

open access: yesSolid Earth
Gassmann's equations have long served as a cornerstone of geophysics and rock physics, widely regarded as exact within their domain of applicability. However, recent studies have questioned their validity, arguing that Gassmann's derivation involves a ...
Y. Alkhimenkov, Y. Y. Podladchikov
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Axial compression and shear behaviour of hollow brick masonry wall panels with plaster-mesh bed-joint reinforcement under summer and winter construction conditions

open access: yesEngineering Science and Technology, an International Journal
Masonry construction in cold regions is highly vulnerable to insufficient early-age curing, which can suppress mortar hydration and weaken the brick–mortar interface, ultimately reducing structural reliability.
Muhammet Şahin   +3 more
doaj   +1 more source

Remarks on non-diagonality conditions for Sierpinski carpets

open access: yesAdvanced Studies in Pure Mathematics, 2019
We prove the equivalence of three different formulations of non-diagonality for Sierpinski carpets given by Barlow, Bass, Kumagai and Teplyaev [5], by Hino [10] and by Kigami [12]. We also derive some geometric property of Sierpinski carpets from the non-diagonality.
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

RADAR LOCATION CONTRAST IN THE REFLECTION OF ELECTROMAGNETIC WAVE FROM TWO OBJECTS

open access: yesНаучный вестник МГТУ ГА, 2018
The paper considers the problem of finding the power flux density of signals reflected from two objects with different symmetric scattering matrices when they are irradiated with a completely polarized wave.
A. I. Kozlov, V. Yu. Maslov
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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