Results 51 to 60 of about 2,325,912 (296)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2017 Diagonal est une revue professionnelle visant à enrichir les pratiques des acteurs de l’urbanisme, de l'habitat, de l’aménagement durable et de l’environnement.
Revue Diagonal
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Reviews on Advanced Materials Science, 2023 This study investigates the seismic performance of a composite structure comprising cold-formed steel and high-strength concrete. Four short shear walls composed of cold-formed steel and high-strength concrete, namely, one specimen without diagonal ...
Gan Min, Yu Yu, Wan Zhonghai
doaj +1 more source
L'ensemble des anciens numéros sur étagère...
, 2019 La Revue Diagonal existe depuis 1973 et a produit 216 numéros en version papier. Nous vous proposons ici les 31 derniers numéros parus et l'intégralité des numéros publiés seront progressivement mis en ligne. Pour tout renseignement, n'hésitez pas à vous
Revue d'urbanisme Diagonal
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Otsu thresholding method based on projection of cross section for image segmentation
Tongxin xuebao, 2014 Due to the disadvantages existing in the conventional three-dimensional Otsu (3D Otsu) method, such as poor anti-noise capability, high computational complexity and difficulty to extend to multilevel thresholding, a new Otsu thresholding method based on ...
Chao-dong FAN +2 more
doaj +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source