Results 111 to 120 of about 4,142,479 (322)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The degradation of music’s object: Deleuze and Guattari’s diagrammatics and musical semiotics

open access: yesSign Systems Studies
This article explores what the music theorist Raymond Monelle called a “certain degradation of the object” in the semiotic analysis of music, that is, the notion that an object or reference seems to be ultimately absent from musical semiotics.
Iain Campbell
doaj   +1 more source

STUDY TO DETERMINE A NEW MODEL OF THE ISHIKAWA DIAGRAM FOR QUALITY IMPROVEMENT [PDF]

open access: yesFiabilitate şi Durabilitate, 2017
The paper presents the results of a study concerning the use of the Ishikawa diagram in analyzing the causes that determine the improvement of the quality of education in a university. All the possible, main and secondary causes that could generate the
Liliana LUCA   +2 more
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Which n-Venn diagrams can be drawn with convex k-gons? [PDF]

open access: green, 2005
Jeremy J. Carroll   +2 more
openalex   +1 more source

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