Results 91 to 100 of about 4,080,086 (295)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Answering a question with Deleuze: How is it possible to think with painting? [PDF]
حکمت و فلسفهIt is commonly believed that thinking is only for philosophical discourse and philosophers. The main question of the research is as follows: How and in what way does thinking “with” painting take place?
Farideh Afarin
doaj +1 more source
Annals of Noninvasive Electrocardiology, 1898 THE law of heredity which was formulated by myself in a memoir entitled “The average Contribution of each several Ancestor to the total Heritage of the Offspring” (Roy. Soc., June 3, 1897, and NATURE, July 8, 1897), and which, as I am exceedingly gratified to learn, is now strongly corroborated by an independent investigation, has recently been ...
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Transforming timing diagrams into knowledge acquisition in automated specification
, 2007 Requirements engineering is an important part of developing programs. It is an essential stage of the software development process that defines what a product or system should to achieve.
Joochim, Tossaporn, Poppleton, Mike
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Calculating the Hubble diagram by perturbation theory [PDF]
, 2010 The effect of density fluctuations upon light propagation is calculated perturbatively in a matter dominated irrotational universe. The starting point is the perturbed metric (second order in the perturbation strength), while the output is the Hubble ...
Bene, Gyula
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source