Results 81 to 90 of about 4,080,086 (295)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Knot Theory and Its Ramifications, 2016 We call a delta diagram any diagram of a knot or link whose regions (including the unbounded one) have 3, 4, or 5 sides. We prove that any knot or link admits a delta diagram. We define and estimate combinatorial link invariants stemming from this definition.
Jablan, Slavik +2 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Diagram Is Worth A Dozen Images
, 2016 Diagrams are common tools for representing complex concepts, relationships and events, often when it would be difficult to portray the same information with natural images.
B Alexe +13 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
From theater to laboratory: two regimes of apparatus in the material assemblages of media culture
Journal of Aesthetics & Culture, 2019 This research examines the apparatus concepts in the last decades of film studies, from the apparatus theory in the 1970s to the revisionist historiography of the early cinema and new media theory after the 1980s.
Sungyong Ahn
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Results of exploring the force impact of 25 tf open-box cars on the rails of curved tracks
Вестник Научно-исследовательского института железнодорожного транспортаIntroduction. Onboarding rolling stock that exerts increased axial loads makes assessing wheels force impact on railway tracks more acute and relevant.
A. Yu. Lugovsky, O. K. Bogdanov
doaj +1 more source
ARS, 2019 RESUMEN En el presente trabajo proponemos un abordaje del fenómeno de la normatividad al que llamamos Estética del Derecho. Nos basamos, para ello, en la propuesta de una Mecanología utilizada por Gilbert Simondon para abordar el fenómeno de la ...
Gonzalo S. Aguirre
doaj +1 more source
, 1998 We show that current experimental knowledge of QCD together with general model independent arguments such as continuity, universality and thermodynamic relations, as well as the information gained from various models can be used to constrain the phase ...
Alford +13 more
core +2 more sources