Results 141 to 150 of about 345,568 (268)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

WCN24-2525 ANALYSIS OF THE IMPACT OF THE CORONAVIRUS PANDEMIC ON THE FOLLOW-UP OF POST KIDNEY TRANSPLANT PATIENTS IN A TRANSPLANT INSTITUTION IN SANTA CATARINA, BRAZIL

Kidney International Reports
Marina Abritta Hanauer, Jyana Morais, Gabriel Abrantes, Helena Balbe, Stephanie Santana, Andressa Zamprogna   +5 more
doaj   +1 more source

Lived experiences and decision making among patients and caregivers choosing conservative kidney management: A qualitative study. [PDF]

Palliat Care Soc Pract
Loh SP, Tan AJQ, Lau WL, Chiang SY, Yeoh LY, Teh SP, Long PWY.   +6 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Phenotype-Specific Heterogeneity in Acute Kidney Injury, Dialysis, and Mortality Among Hospitalized Patients with Chronic Kidney Disease: A National Retrospective Cross-Sectional Study. [PDF]

J Clin Med
Tai B, Okonkwo C, Snyder D.
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

WCN25-992 STRATEGIES TO DECREASE HEPATITIS C BURDEN AND IMPROVE SAFETY, COST-EFFECTIVELY IN THE HEALTH SYSTEM AMONG PATIENTS ON HEMODIALYSIS: LESSONS FROM LOW RESOURCE SETTINGS

Kidney International Reports
Suresh Sankarasubbaiyan, Savitha Kasiviswanathan, Venkatraman Ganapathy, Rajesh P, Devender Pandey, Kamal D. Shah   +5 more
doaj   +1 more source

Glucose monitoring during hemodiafiltration: a comparison of continuous, capillary, and dialysis-line measurements. [PDF]

Clin Kidney J
Carvalho MS, Kojima CA, Rocha EP, Costa DM, Magalhães AO, Borges CM, Rocha EVS, Fernandes AS, Resende LLG, Leal A, Alves L, Cuppari L, Elias RM.   +12 more
europepmc   +1 more source