Results 191 to 200 of about 654,312 (306)

WCN25-992 STRATEGIES TO DECREASE HEPATITIS C BURDEN AND IMPROVE SAFETY, COST-EFFECTIVELY IN THE HEALTH SYSTEM AMONG PATIENTS ON HEMODIALYSIS: LESSONS FROM LOW RESOURCE SETTINGS

Kidney International Reports
Suresh Sankarasubbaiyan, Savitha Kasiviswanathan, Venkatraman Ganapathy, Rajesh P, Devender Pandey, Kamal D. Shah   +5 more
doaj   +1 more source

Updates in Hospital Medicine: Nephrology. [PDF]

J Brown Hosp Med
Garsuta CGL, Mahmoud HM, Gordon LB.
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

WCN24-909 ARTERIAL HYPERTENSION (AH) IN RENAL TRANSPLANT RECIPIENTS (RT) RISK FACTORS AND INPACT

Kidney International Reports
Ndiaga Sow, Wissal Sahtout, Awatef Azzabi, Yosra Zmanter, Sanda Mrabet, Rihem Dahmane, Ferdaous Sabri, Asma Fradi, Nesrine Thabet, Mehdi Slim, Olfa Mahfoud, Raja Boukadida, Yosra Guedri, Elias Neffeti, Narjes Ben Aicha, Dorsaf Zellama   +15 more
doaj   +1 more source

Malnutrition and fluid overload as independent predictors of mortality in dialysis patients: A multicenter cohort study in Colombia. [PDF]

Sci Prog
Vargas-Correa V, Orellana-Cáceres JJ, Vargas-Alvarado E, Gómez-Jordan S, Tuta-Quintero E.   +4 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Decisional Conflict and Patient Experiences in Dialysis Treatment Decision-Making: A Mixed-Methods Study in a Portuguese Cohort. [PDF]

Healthcare (Basel)
Bispo I, Rego F, Rego G.
europepmc   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source