Results 181 to 190 of about 654,312 (306)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Differential serum dynamics of apelin, elabela, and angiotensinogen in CKD and haemodialysis: insights into peptide modulation across the dialysis procedure. [PDF]

Ren Fail
Serwin NM, Cecerska-Heryć E, Grygorcewicz B, Cejko M, Jerzyk A, Ćwikła K, Spajzer E, Manelska A, Woźniak P, Gomółka A, Cader-Ptak A, Bąk K, Lisak M, Opara-Bajerowicz M, Wojciuk B, Suwała M, Serwin K, Wiśniewska M, Dołęgowska B.   +18 more
europepmc   +1 more source

The interplay and interaction between frailty and acute kidney injury

, 2020
Lameire, Norbert, Van Biesen, Wim, Vanmassenhove, Jill   +2 more
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

WCN24-2525 ANALYSIS OF THE IMPACT OF THE CORONAVIRUS PANDEMIC ON THE FOLLOW-UP OF POST KIDNEY TRANSPLANT PATIENTS IN A TRANSPLANT INSTITUTION IN SANTA CATARINA, BRAZIL

Kidney International Reports
Marina Abritta Hanauer, Jyana Morais, Gabriel Abrantes, Helena Balbe, Stephanie Santana, Andressa Zamprogna   +5 more
doaj   +1 more source

Nephrologist Affiliation With Dialysis Facilities and Patient Trajectories in End-Stage Kidney Disease.

JAMA Netw Open
Alinezhad F, Young GJ, Hirth R, Cao J, Post B.   +4 more
europepmc   +1 more source

Health care resource utilization and costs of major bleeding in patients with and without dialysis-dependent end-stage kidney disease: a retrospective study. [PDF]

Res Pract Thromb Haemost
Roetker NS, Victores A, Kou C, Bash LD, Ramey DR, Ke X, Bonaca MP, Wetmore JB.   +7 more
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Determinants of poor sleep quality in hemodialysis patients: a multicenter cross sectional study in Sri Lanka. [PDF]

Front Med (Lausanne)
Weerakoon D, Perera R, Ambillapitiya R, Waidyasuriya S, Herath M, Tudugala R, Bodhipaksha R, Gunaratne C, Perera N, Herath N, Dassanayake D, Albert S, Jayasekara K.   +12 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source