Results 221 to 230 of about 654,312 (306)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

WCN25-785 ASSESSMENT OF PAIN DUE TO VASCULAR ACCESS CANNULATION AMONG PATIENTS ON HEMODIALYSIS – A MULTI-CENTRIC CROSS-SECTIONAL STUDY IN INDIA, 2023

Kidney International Reports
Kamal D Shah, Vidya Joshi, Ankit Agarwal, Devender P, Rajesh P, Savitha Kasiviswanathan, Suresh Sankarasubbaiyan, Vivekanand Jha   +7 more
doaj   +1 more source

On the self-management ability of peritoneal dialysis patients: a cross-sectional study with a mixed approach. [PDF]

PLoS One
Sun J, Zhang Y, Zhao M, Wang Y, Li Y, Zhang H.   +5 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

"It's more than connecting tubes": a qualitative inquiry into nurses' emotional labor in dialysis units. [PDF]

BMC Nurs
Almulhim MY, Shalaby SA.
europepmc   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

A Study of Intradialytic Complications in Chronic Kidney Disease Patients. [PDF]

Cureus
Nilugal B, Biradar SM, Patil S.
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

WCN24-1790 HEMOLYTIC UREMIC SYNDROME SECONDARY TO URINARY INFECTION DUE TO ESCHERICHIA COLI: DOES IT EXIST? CASE REPORT

Kidney International Reports
Ivanna Gardarian, Vanesa Fauda, Ana Saez, Nadia Ortiz, Claudia Yeneris, Luz Bendersky, Rocio Busolo, Cenith Contrera, Natalia Salazar, Juan Ibañez, Marta Adragna   +10 more
doaj   +1 more source