Results 71 to 80 of about 4,577,181 (267)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Nondestructive measurement of capillary tube internal diameter [PDF]

open access: yes, 1975
Technique provides nondestructive method of making quick, accurate determination by measuring electrical resistance of capillary tube when it is filled with electrolyte of known conductivity.
Ho, W. W., Love, A. W., Vanmelle, M. J.
core   +1 more source

Diameter dependence of SiGe nanowire thermal conductivity

open access: yes, 2011
We theoretically compute the thermal conductivity of SiGe alloy nanowires as a function of nanowire diameter, alloy concentration, and temperature, obtaining a satisfactory quantitative agreement with experimental results.
Mingo, N., Wang, Zhao
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Fullerene graphs of small diameter

open access: yes, 2016
A fullerene graph is a cubic bridgeless plane graph with only pentagonal and hexagonal faces. We exhibit an infinite family of fullerene graphs of diameter $\sqrt{4n/3}$, where $n$ is the number of vertices. This disproves a conjecture of Andova and \v{S}
Nicodemos, Diego, Stehlík, Matěj
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Cops and Robbers on diameter two graphs [PDF]

open access: yes, 2014
In this short paper we study the game of Cops and Robbers, played on the vertices of some fixed graph $G$ of order $n$. The minimum number of cops required to capture a robber is called the cop number of $G$.
Wagner, Zsolt Adam
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Retinal Microvascular Diameters are Associated with Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2023
Jing Feng,1– 3 Xiaohua Xie,4 Zhenjie Teng,4,5 Wenjie Fei,1,2 Yunfeng Zhen,2 Jingzhen Liu,2 Liqun Yang,2 Shuchun Chen1– 3 1Department of Endocrinology, Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China; 2Department of ...
Feng J   +7 more
doaj  

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