Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee +10 more
wiley +1 more source
Development of a Molecular-Imprinted-Polymer based sensor for the electrochemical determination of Triacetone Triperoxide (TATP) [PDF]
.The explosive triacetone triperoxide (TATP), which can be prepared from commercially readily available reagents following an easy synthetic procedure, is one of the most common components of improvised explosive devices (IEDs).
Ansari +19 more
core +2 more sources
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
Synthesis and characterization of [Fe(BPMEN)-ACC]SbF 6 : a structural and functional mimic of ACC-oxidase † [PDF]
International audienceA mononuclear Fe(II) complex bearing 1-aminocyclopropane-1-carboxylic acid (ACCH) was synthesized and characterized. X-ray crystallography demonstrated that ACC binds to the Fe(II) ion in a bidentate mode constituting the first ...
Avenier, F +5 more
core +3 more sources
DNA Nanostructure‐Guided Synthesis of Nanomaterials and Their Applications
This review summarizes the state‐of‐the‐art progress on the synthesis of nanomaterials, e.g., inorganic nanomaterials, organic polymers, and liposomes, based on DNA templates, and several emerging applications of these nanomaterials are also included.
Yiming Xie +3 more
wiley +1 more source
Hen breed and age – Lohmann Pink‐shell (LMP), Dongxiang Green‐shell (DXG), Dongxiang Pink‐shell (DXP), first‐laid Dongxiang Green‐shell (DXGF), and first‐laid Dongxiang Pink‐shell (DXPF) – significantly influence egg quality, biochemical traits, and amino acid composition, with yolk EAA/TAA ratios of 54.53–55.33 and albumen ratios of 53.38–53.71 ...
Lanlan Yi +8 more
wiley +1 more source
Citrus is highly sensitive to salt stress, and little efforts have been successful microbiologically to mitigate such abiotic stress. In this background, trifoliate orange [Poncirus trifoliata (L.) Raf.] seedlings were inoculated with Diversispora ...
PENG WANG +3 more
doaj +1 more source
Human Copper-Containing Amine Oxidases in Drug Design and Development
Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3 ...
Serhii Vakal +3 more
doaj +1 more source
Functionality Enhancement of Pullulan‐Based Composites for Food Packaging Applications
ABSTRACT Contemporary research in food packaging is focused on developing sustainable alternatives to petroleum‐based materials. Pullulan, a microbial biopolymer traditionally employed as a food additive, is harnessing interest for food packaging applications due to its exceptional film‐forming ability, biodegradability, and nontoxic nature.
Bibek Bahadur Shrestha +2 more
wiley +1 more source
HPLC–UV assay for the evaluation of inhibitors of plasma amine oxidase using crude bovine plasma
Recently, we have described a method for evaluation of plasma amine oxidase (PAO) inhibitors, which monitors the formation of 6-(5-phenyl-2H-tetrazol-2-yl)hexanal from the corresponding amine substrate by HPLC with UV-detection using purified bovine PAO.
Kira Mergemeier +2 more
doaj +1 more source

