Results 71 to 80 of about 474,397 (233)

A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies

open access: yesVeterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Heat stress caused by high temperature and humidity compromises broiler health, welfare, and productivity by reducing feed intake, growth performance, and feed efficiency, while increasing mortality, oxidative stress, metabolic disturbances, intestinal dysfunction, gut dysbiosis, immune suppression, and meat quality deterioration.
Maksuda Begum   +8 more
wiley   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández   +6 more
wiley   +1 more source

Diamine Oxidase in Rabbit Liver [PDF]

open access: yesEuropean Journal of Biochemistry, 1973
Subfractionation of the microsomes according to Dallner [4] showed that diamine oxidase is concentrated in the smooth microsomes.Centrifugation of the post‐mitochondrial supernatant treated with CsCl on a discontinuous three‐step gradient consisting of 0.8 M sucrose (density 1.12 g/ml) layered on 1.3 M sucrose (density 1.20 g/ml) resulted in three ...
M. P. Argento Ceru   +2 more
openaire   +3 more sources

Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides

open access: yesChemBioChem, Volume 27, Issue 15, 14 August 2026.
Using a comprehensive set of nucleic acid‐related molecules, from individual nucleobases to oligonucleotides, we demonstrate the selective binding of Cu+ to cytosine‐containing oligonucleotides. Contrary to guanine‐containing oligonucleotides, cytosine‐rich oligonucleotides form a Cu+‐complex with a clear near‐UV signature and are able to stop redox ...
Joana Pereira   +3 more
wiley   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni   +12 more
wiley   +1 more source

The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs. [PDF]

open access: yesPLoS ONE, 2012
UnlabelledNon-steroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity drug reactions. Histamine is released in the allergic response to NSAIDs and is responsible for some of the clinical symptoms.
José A G Agúndez   +14 more
doaj   +1 more source

Amperometric Biosensor Based on Diamine Oxidase/Platinum Nanoparticles/Graphene/Chitosan Modified Screen-Printed Carbon Electrode for Histamine Detection

open access: yesItalian National Conference on Sensors, 2016
This work describes the development and optimization studies of a novel biosensor employed in the detection and quantification of histamine in freshwater fish samples.
I. Apetrei, C. Apetrei
semanticscholar   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

open access: yesSmall, Volume 22, Issue 46, 18 August 2026.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem   +12 more
wiley   +1 more source

Nutrients regulate diamine oxidase release from intestinal mucosa

open access: yes, 1998
Diamine oxidase is continuously released from the intestinal mucosa and carried to the circulation by the lymphatics. The effect of nutrients on this release was examined. Rats were prepared with duodenal and intestinal lymph cannulas.
Patrick Tso, Armin Wollin, Xiaolin Wang
core   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao   +7 more
wiley   +1 more source

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