Results 41 to 50 of about 265,577 (266)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The structure of the diamond [PDF]
Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1913 Abstract There are two distinct methods by which the X-rays may be made to help to a determination of crystal structure. The first is based on the Laue photograph and implies the reference of each spot on the photograph to its proper reflecting plane within the crystal.
Bragg, W. H., Bragg, W. L.
openaire +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Life, 2021 Chlamydiae are strict intracellular pathogens residing within a specialised membrane-bound compartment called the inclusion. Therefore, each infected cell can, be considered as a single entity where bacteria form a community within the inclusion.
Patrick Phillips +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
On the Conduction Mechanism in Diamond 2-D Hole Gas Field Effect Transistors
IEEE AccessDiamond two-dimensional hole gas (2DHG) field-effect transistors are an emerging device class with significant practical potential. To date, hole mobility in such devices has been largely assessed using Hall effect measurements, with only limited ...
Andrew J. Walker +3 more
doaj +1 more source
Fast-feedback for unattended data collection at Diamond Light Source [PDF]
Structural DynamicsDiamond Light Source's I03 beamline now spends most of its time in "Unattended Data Collection" mode. To maximise throughput, it is critical that as little time is spent waiting for x-ray centering as possible. In this talk, I will describe the GPU-based
Nicholas Devenish +2 more
doaj +1 more source
LED-pump-X-ray-multiprobe crystallography for sub-second timescales
Communications Chemistry, 2022 Time-resolved single-crystal X-ray diffraction experiments largely focus on timescales shorter than microseconds, whereby slower population dynamics are missed.
Lauren E. Hatcher +12 more
doaj +1 more source