Results 41 to 50 of about 576,041 (298)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Free for authors, free for readers, free from publisher, free formatting and free opinion: This is Free Neuropathology

Free Neuropathology, 2020
Free for authors, free for readers, free from publisher, free formatting and free opinion: This is Free ...
Werner Paulus
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Die Rolle der AG Universitätsverlage in der Wissenschaftskommunikation

o-bib. Das offene Bibliotheksjournal
Die AG Universitätsverlage hat sich seit ihrer Gründung vor zwanzig Jahren als ein zukunftsweisendes Netzwerk für wissenschaftliche Verlage im deutschsprachigen Raum etabliert.
Barbara Ziegler, Dagmar Schobert, Isabella Meinecke, Margo Bargheer, Regine Tobias, Ursula Arning   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Oral evidence [PDF]

, 2013
Oral evidence given to the House of Commons BIS Select Committee Inquiry into Open ...
Eve, Martin Paul
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Diamond Open Access Landscape in Croatia: DIAMAS Survey Results

Publications
As open science initiatives address the crisis in scholarly communication driven by commercialisation, diamond open access publishing—promoting equity for authors and readers—has emerged as a focal point in open access scholarly publishing.
Jadranka Stojanovski, Danijel Mofardin
doaj   +1 more source

Diamonds's Temperature: Unruh effect for bounded trajectories and thermal time hypothesis

, 2003
We study the Unruh effect for an observer with a finite lifetime, using the thermal time hypothesis. The thermal time hypothesis maintains that: (i) time is the physical quantity determined by the flow defined by a state over an observable algebra, and ...
Bisognano J J, Bisognano J J, Carlo Rovelli, Connes A, Culetu H, Davies P C W, Fedotov A M Narozhny N B Mur V D, Fulling S A, Haag R, Hislop P D, Landau L, Leinaas J M, Lin S Y, Pierre Martinetti, Rovelli C, Rovelli C, Rovelli C, Sewell G L, Sewell G L, Streater R F, Takesaki M, Unruh W G, Vallisneri M, Vanzella D A T Matsas G E A, Wald R M   +24 more
core   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source